Staff Scientist
About The Position
The Staff Scientist will lead research on engineering microorganisms for therapeutic use, focusing on microbial platforms that deliver therapeutic molecules, including applications in cancer immunotherapy. The role involves developing genetic engineering tools, designing and evaluating engineered strains, studying interactions with mammalian hosts, and conducting molecular biology, microbiology, and preclinical experiments to assess function, efficacy, and mechanisms of action. The ideal candidate is an independent, innovative researcher who can develop experimental approaches, analyze complex datasets, collaborate across disciplines, and contribute to publications and grant proposals. This at-will position is wholly or partially funded by contractual grant funding; continued employment depends on continued receipt of grant funds and satisfactory job performance. The position is an individual-contributor role in a wet-lab environment, scheduled for 40 hours per week. The University of Chicago identifies the role as benefits-eligible. The listed salary range is $70,000–$90,000.
Requirements
- PhD in a related field.
- Two to five years of work experience in a related job discipline.
- Knowledge and skills relevant to the position, including research experience.
Nice To Haves
- Postdoctoral researcher training.
- Prior experience writing and preparing manuscripts.
- Strong knowledge of microbiology, molecular biology, synthetic biology, and microbial genetic engineering.
- Experience with anaerobic microbial cultivation, genetic manipulation, and characterization of engineered microorganisms.
- Experience with recombinant protein expression, protein secretion, and molecular and biochemical assays.
- Knowledge of mammalian cell culture, host–microbe interactions, and preclinical animal models, including tumor models.
- Strong skills in experimental design, troubleshooting, quantitative data analysis, and scientific interpretation.
- Ability to independently plan, organize, and carry out complex research projects.
- Ability to communicate scientific findings clearly through publications, presentations, and written reports.
- Ability to collaborate with multidisciplinary research teams and train laboratory personnel.
Responsibilities
- Design, develop, and optimize genetic engineering tools and experimental assays for anaerobic microorganisms, including Bifidobacterium species.
- Engineer microbial strains for controlled gene expression, therapeutic protein production and secretion, and targeted delivery of biological therapeutics.
- Design and conduct molecular biology, microbiology, and cell-based experiments to characterize engineered microbial functions and host–microbe interactions.
- Develop and execute preclinical studies using animal models to evaluate microbial colonization, therapeutic efficacy, and host responses.
- Develop and test scientific hypotheses, analyze experimental data, and interpret findings to guide research.
- Collaborate with interdisciplinary research teams to develop and evaluate novel microbial therapeutics.
- Collect and analyze data and provide scientific or intellectual information to facilitate and promote research projects.
- Review laboratory protocols and train others on new techniques; manage complex research datasets.
- Lead contributions to scientific writing and publications, including protocols and grants.
- Train new laboratory personnel.
- Perform other related work as needed.
Benefits
- Benefits eligibility, including access to health, retirement, and paid time off programs.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
