Staff Bioinformatics Scientist
About The Position
At Caris, we are dedicated to transforming cancer care and improving lives through precision medicine. We leverage cutting-edge molecular science and AI to provide unique answers based on a patient's DNA. Our mission extends beyond cancer, aiming to push the frontiers of medicine and lead a revolution in healthcare. We are looking for passionate individuals to join us in improving the human condition across multiple diseases. The Staff Bioinformatics Scientist will lead a team of bioinformatics scientists in developing, validating, implementing, and supporting next-generation sequencing (NGS) bioinformatics pipelines and analytical workflows in a clinical or translational genomics setting. This role requires technical expertise, project leadership, and people management to deliver reliable, scalable, and compliant bioinformatics solutions for research, assay development, validation, and clinical operations. The position involves close collaboration with laboratory, clinical, software engineering, IT, quality, and scientific stakeholders to enhance genomic testing capabilities and operational excellence.
Requirements
- PhD degree with experience in Bioinformatics, Computational Biology, Biostatistics, Computer Science, Genomics, Molecular Biology, or a related field.
- Minimum of 5 to 8 years of hands-on bioinformatics experience supporting NGS pipeline development, validation, or production operations.
- Minimum of 2 to 4 years of people leadership experience.
- Demonstrated experience managing projects and coordinating cross-functional stakeholders.
- Strong knowledge of NGS data analysis methods, quality metrics, bioinformatics workflows, and genomic data interpretation.
- Strong programming and scripting skills using Python, Bash, SQL, R, or equivalent tools.
- Experience with AWS or other cloud computing platforms supporting genomic data processing and storage.
- Strong communication, collaboration, organizational, and problem-solving skills.
- Proficiency in Microsoft Office Suite.
Nice To Haves
- Experience supporting both research and clinical bioinformatics environments.
- Experience with liquid biopsy, MRD, cancer early detection, ctDNA analysis, or related applications.
- Experience with multi-omic data integration and advanced genomic analyses.
- Experience working in CLIA, CAP, NYSDOH, FDA, ISO, or comparable regulated environments.
- Experience preparing validation reports, technical documentation, regulatory support materials, or scientific publications.
Responsibilities
- Lead, coach, mentor, and develop a team of bioinformatics scientists, including hiring support, onboarding, performance management, career development, and workload prioritization.
- Manage day-to-day bioinformatics operations and ensure timely delivery of high-quality analytical solutions across development, validation, and production activities.
- Establish project plans, priorities, timelines, and resource allocations for team initiatives and cross-functional programs.
- Oversee development, optimization, validation, and maintenance of NGS bioinformatics pipelines and workflows.
- Support end-to-end genomic data analysis, including quality control, alignment, variant calling, annotation, filtering, interpretation support, and reporting workflows.
- Lead analytical development and validation activities for NGS assays, including performance assessment, reproducibility studies, concordance analysis, quality metrics, and documentation.
- Drive implementation of scalable, automated, and reproducible computational workflows using software development and bioinformatics best practices.
- Collaborate with software engineering and IT teams to support cloud-based infrastructure, workflow execution, data storage, monitoring, and system performance.
- Ensure bioinformatics processes comply with applicable quality, regulatory, documentation, privacy, and security requirements.
- Partner with laboratory scientists, molecular pathologists, clinical teams, statisticians, and researchers to translate scientific and clinical requirements into analytical solutions.
- Monitor project progress, identify risks and dependencies, communicate status updates, and facilitate resolution of technical and operational challenges.
- Investigate and resolve complex pipeline, assay, and data quality issues while supporting production operations as needed.
- Serve as a technical subject matter expert for bioinformatics workflows, genomic analyses, and assay validation efforts.
- Stay current on emerging technologies, tools, methodologies, and industry best practices in genomics and bioinformatics.
Benefits
- All required training will be assigned based on job responsibilities.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
