Staff Bioinformatics Scientist

Illumina•San Diego, CA
•$155,600 - $233,400

About The Position

Our team specializes in developing a fast and accurate platform called DRAGEN for the secondary analysis of NGS genomic data. The platform covers a wide range of pipelines spanning germline and somatic analysis (WGS and targeted; tumor/normal and tumor-only), DNA and RNA workflows, and variant classes including small variants, CNVs, and structural variants. We are looking for a highly driven and talented Staff Bioinformatics Scientist to join our methods development team to work on secondary analysis algorithms. The ideal candidate will have a strong background in computer science, algorithms, statistics, or digital signal processing in addition to expertise in genomics and next generation sequencing. The candidate should be a proven team player and will contribute to the production software codebase. This role will focus on software development for structural variant detection, pangenome references, graph-based algorithms, and NGS assembly methods.

Requirements

  • Typically requires a minimum of 8 years of related experience with a Bachelor’s degree; or 6 years and a Master’s degree; or a PhD with 3 years of experience; or equivalent experience.
  • Experience developing next generation sequencing data analysis methods.
  • Extensive experience in an object-oriented programming language; C++ preferred.
  • Strong background in computer science algorithms relevant to bioinformatics.
  • Ability to efficiently leverage AI-assisted tools in development to rapidly iterate and prototype ideas.
  • Strong communication skills and ability to describe complex analyses to audiences with diverse backgrounds.
  • Ability to contribute independently and collaboratively, take ownership of assigned tasks, and excel in a fast-paced environment.
  • Experience using version control systems such as Git.
  • Knowledge or background in NGS-based methods for assembly, structural variant detection, and cancer-related applications would be especially well suited to this role.
  • Willingness to learn and grow with an exceptionally talented group of scientists and engineers!

Nice To Haves

  • Experience with multi-threading and memory management techniques.
  • Knowledge and experience with probability and statistics or machine learning.
  • Knowledge and experience with a wide range of bioinformatics tools.
  • Familiarity with professional software development practices (testing, CI/CD, debugging, source control).
  • Demonstrated success in collaborating in a team environment and delivering high-quality software products using agile development methodologies.

Responsibilities

  • Design, prototype, and implement innovative computational or statistical algorithms to extract meaningful biological signal from sequencing assays.
  • Implement algorithms in production-grade C/C++ software.
  • Collaborate deeply with interdisciplinary teams (QC/QA test teams, FPGA teams, SW teams, clinical genomics teams).
  • Engage with external scientific teams to build product credibility and define emerging requirements.
  • Clearly communicate technical methods and findings across internal teams with diverse expertise.

Benefits

  • access to genomics sequencing
  • family planning
  • health/dental/vision
  • retirement benefits
  • paid time off
  • one of our variable cash programs (bonus or commission)
  • equity as part of the compensation package
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