Sr. Scientist - Mass Spec Production (LC-MS/MS)

KCAS Bio • Kansas City, KS

7d

About The Position

The Sr. Scientist works in KCAS Bio’s Mass Spec Bioanalysis Production group, carrying out all aspects of regulated bioanalytical studies from study setup through reporting. The role applies bioanalytical and scientific principles, regulatory expectations, and LC-MS/MS expertise to deliver high-quality, data-integrity-focused work in a GLP-compliant environment. The team uses LC-MS/MS and sophisticated sample preparation methods to support drug discovery, preclinical, and clinical studies, including analysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues.

The position serves as lead scientist on assigned studies, providing technical guidance and training to junior staff, communicating with clients, and coordinating study timelines and deliverables. It also has final authority for sample identification and supports resolution of audit findings, deviations, compliance issues, and technical challenges. The role ensures study activities meet protocols, SOPs, and GLP requirements and supports audit readiness and inspections.

KCAS Bio describes itself as a fast-growing contract research organization headquartered in Kansas City. Its stated benefits include company-sponsored events, career development through KCAS University, wellness and inclusion activities, a stock ownership program, access to the latest technology, and paid time off to volunteer.

Requirements

• Bachelor’s, Master’s, or PhD in Chemistry, Biochemistry, or a related field.
• At least 5 years of experience in a bioanalytical laboratory environment.
• Extensive hands-on experience in a GLP-regulated laboratory environment.
• Strong experience with bioanalytical sample preparation and quantitative LC-MS/MS workflows.
• Experience executing regulated studies, including data review, reporting, and audit support.
• Demonstrated ability to troubleshoot technical and operational issues in a production environment.
• Experience interacting with Quality Assurance and supporting audits and inspections.

Nice To Haves

• Prior experience acting as a study lead or in a Principal Investigator–type role.

Responsibilities

• Execute and oversee assigned study phases, including sample preparation, LC-MS/MS analysis, data review, and report generation in a regulated environment.
• Act as lead scientist on studies, providing work direction, technical guidance, and training to junior scientific staff.
• Manage client communication related to study conduct and data delivery.
• Interact with Quality Assurance to resolve audit findings, deviations, and compliance-related issues.
• Make final determinations regarding sample identification, including resolving discrepancies with clinical sites or clients.
• Manage study timelines and deliverables and communicate status to management and clients.
• Ensure study activities comply with study protocols, SOPs, and GLP regulatory requirements.
• Review data for accuracy, completeness, and integrity before reporting.
• Support audit readiness and participate in client and regulatory inspections as needed.
• Provide technical troubleshooting support for assay performance and operational challenges in a production environment.
• Perform duties in a manner that supports the company’s brand, mission, vision, and values.

Benefits

• Company-sponsored events, including food trucks, family days, and spirit days.
• Career development through KCAS University.
• Opportunities to connect with employees around wellness, inclusion, and community outreach.
• Stock ownership program.
• Access to the latest technology.
• Paid time off to volunteer.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior