Sr Scientist II, Multispecific Antibody Engineering, Oncology

AbbVie•Worcester, MA

12d•$109,500 - $208,500

About The Position

Discovery Biotherapeutics at AbbVie is seeking a highly skilled, self-motivated scientist to join a dynamic team supporting the design, engineering, and manufacturing of multispecifics. This position will have a significant impact by managing a group of scientists focused on design, production, and characterization of multispecific biopharmaceutical products. The ideal candidate will have extensive experience with biologics and multispecific production platforms, analytical characterization, and a proven track record of implementing multispecific engineering and production strategies to advance early- and late-stage discovery programs in ADCs and immuno-oncology. The ideal candidate should also have experience managing a small multispecific engineering team in a discovery setting. The successful applicant will be an enthusiastic, creative scientist who makes tangible contributions to continuous improvement and innovation within the organization.

Requirements

PhD or MS degree in Biochemistry, Biochemical engineering or related disciplines
+ (PhD) or 12+ (MS) years of experience in multispecific engineering or antibody engineering
Experience with protein, biologics, fragments, or multispecifics (e.g. bispecifics, trispecifics, bispecific protein fusions) design, expression and purification
In-depth knowledge of the multispecific landscape, trends in design, and application across therapeutic areas including immunology, oncology, and neuroscience
Ability to recognize emerging areas of interest in multispecific engineering, antibody engineering, and related fields, and make connections between research ideas to advance platforms and programs
Excellent organizational skills and the ability to manage multiple projects simultaneously
Team player with the ability to operate in a fast-paced multi-disciplinary environment
Candidate must be a goal-oriented team player with excellent verbal and written communication skills and strong can-do attitude

Nice To Haves

Experience with sequence analysis tools (Vector NTI, Geneious, Genedata)
Experience with mass spectrometry analysis and software (Protein Metrics)
Experience with CRO coordination for production
Expert understanding of current state of protein expression/separation/analytical technologies
Extensive knowledge of biologic pipeline progression from exploratory through candidate nomination with program management experience preferred
Experience managing direct reports and providing performance evaluations and development opportunities
Recognized in the scientific community through a sustained record of peer-reviewed publications and patents preferred

Responsibilities

Design, engineering, and production of multispecific biologics to support AbbVie’s Oncology therapeutic area; apply design and engineering experience with multispecific biologics for ADC and immuno-oncology applications.
Manage a group of scientists within the multispecific team, focusing on the design, production, characterization of multispecific biologics, and management of multispecific inventory.
Serve as the biologics lead on multispecific biologics projects, coordinating activities and transitions from hit generation through candidate nomination.
Serve as a multispecific engineering representative on cross-functional teams; recognized as an expert in multispecific design and production.
Identify and solve technical problems independently, conceive, and implement innovative processes in research ideas.
Present original work internally across departments and at internal and external scientific conferences; may author or co-author peer-reviewed scientific papers or patents.