Sr. Manager, Clinical Project Management

Rapport Therapeutics•Boston, MA

3d•$160,000 - $180,000•Hybrid

About The Position

When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors). Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies. We are excited about the potential of our lead program, RAP-219. Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder. The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are! This role is based in Boston, MA with onsite presence required Monday-Wednesday

Requirements

Bachelor's degree in Life Sciences or a related field.
8+ years of experience in biotech or pharmaceutical environments with significant experience in Clinical Operations, study start-up, feasibility, clinical project management, or trial management.
Strong clinical project/program management experience with oversight of multiple studies or programs across a portfolio.
Experience developing and implementing operational excellence, process improvement, or center-of-excellence initiatives within Clinical Operations.
Strong understanding of clinical trial execution, ICH-GCP, global regulatory requirements, and inspection readiness expectations.
Proven ability to influence and align cross-functional stakeholders, including Clinical Operations, Clinical Development, Regulatory Affairs, Medical Affairs, and external partners.
Experience managing CRO performance and complex vendor relationships.
Strong analytical skills with experience developing metrics, dashboards, and executive-level reporting.
Experience working in a small- to mid-sized biotechnology company where adaptability, hands-on execution, and collaboration are critical.
Excellent communication, organizational, leadership, and problem-solving skills.

Responsibilities

Support the successful delivery of the Clinical Operations portfolio by providing oversight of study execution, coordinating cross-functional activities, monitoring portfolio performance, and driving operational excellence across clinical programs.
Provide holistic oversight of Clinical Operations programs, ensuring alignment of study execution activities across the portfolio.
Develop and maintain integrated program plans, timelines, milestones, dependencies, and operational dashboards to support portfolio-level decision-making.
Monitor program performance, key deliverables, risks, and resource needs, escalating issues and driving cross-functional resolution as needed.
Partner with Clinical Operations leadership, study teams, and functional stakeholders to ensure consistent execution and achievement of program objectives.
Lead cross-functional governance forums and portfolio reviews, providing clear communication of status, risks, mitigation strategies, and operational insights.
Develop reporting and analytics to assess operational performance, cycle times, and portfolio health, driving continuous improvement initiatives.
Author and maintain operational procedures, governance frameworks, training materials, and documentation supporting program execution.
Mentor team members and foster a culture of operational excellence, collaboration, accountability, and continuous improvement.