Sr Director, Medical Director (Obesity and Metabolic Programs)

Structure Therapeutics•South San Francisco, CA

15h•Hybrid

About The Position

Structure Therapeutics develops life-changing medicines for patients using advanced structure-based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical-stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions. Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location. Position Summary: Reporting to the Executive Director, Medical Affairs & Advocacy Engagement, the Sr Director, Medical Director at Structure Therapeutics will lead the development and execution of the Medical Strategy, gathering and synthesizing external insights—including treatment patterns, unmet medical needs, and competitive intelligence— across all metabolic programs. This role is critical in shaping scientific engagement and communications, identifying evidence gaps, and supporting lifecycle management. The individual will serve as a key scientific expert internally and externally, ensuring alignment across clinical development, regulatory, and commercial readiness efforts. As a trusted scientific partner, the Medical Director builds and sustains relationships with key opinion leaders, investigators, healthcare professionals, and patient communities, facilitating the exchange of scientific information related to the company’s pipeline and therapeutic focus areas. The role requires a high level of expertise in interpreting and communicating clinical and translational data, particularly in fast-evolving therapeutic landscapes. The Medical Director plays a pivotal role in supporting clinical development programs by identifying and engaging top investigators and providing key insights that inform study design and execution.

Requirements

MD, PharmD, or PhD in a relevant scientific field
10+ years in biotech/pharma
Strong background in metabolic diseases (e.g., obesity, type 2 diabetes), global experience a plus
Prior experience as Medical Director or equivalent in Medical Affairs
Deep scientific expertise in metabolism.
Direct experience in obesity, type 2 diabetes, or incretin-based therapies is preferred
Experience with protocol design in metabolism, particularly incretin therapies
Strong communication and presentation skills
Leadership and team management ability
Strategic thinking with execution focus

Responsibilities

Develop and execute a comprehensive Medical Strategic Plan, including insight generation, data dissemination, and medical communications, across all obesity and related metabolic programs
Lead Publication Strategy across all programs (abstracts, manuscripts, congress presentations)
Build relationships with Key Opinion Leaders (KOLs), academic institutions, and healthcare providers
Present clinical and scientific data on metabolic therapies.
Represent the company at medical and community congresses, advisory boards
Lead high-level scientific discussions on disease state and treatment landscape
Support Investigator-Initiated Trials (IITs) and real-world evidence studies
Gather and synthesize medical insights from HCP interactions
Inform clinical development plans and lifecycle management
Partner with: Clinical development (trial design considerations, medical insights, unmet medical need)
Partner with: Clinical Operations (investigator needs and engagement)
Partner with: Market access (value messaging)
Partner with: Commercial teams (compliant scientific support)
Review materials for scientific accuracy and compliance as representative in Medical Legal Regulatory (MLR) review process
Ensure all activities comply with regulatory and ethical standards