Spatial Sequencing Associate
About The Position
As a Spatial Sequencing Associate 2, you will support a collaborative team of engineers and scientists to run customer tissue samples on the G4X Spatial Sequencer. The ideal candidate will have experience in standard molecular biology techniques for handling nucleic acids (e.g., DNA/RNA purification, PCR amplification, isothermal amplification, and library preparation for next generation sequencing) and be familiar with common enzymes that interact with DNA/RNA. Experience with next generation DNA sequencing (instrumentation and analysis) and handling of tissues on flow cells is a plus. Expertise in immunoassays (IHC, IF, ISH), familiarity with microscopy-based readouts (particularly fluorescence) and experience with multiplexed assay workflows are essential. You will provide guidance to assay developers to identify appropriate controls, optimize workflows, and implement enhancements that improve assay robustness and reliability.
Requirements
- BS in a Science or Engineering field or 5 years of working experience in equivalent field.
- Strong molecular biology laboratory skills, demonstrated by work experience.
- Hands-on experience with multiplexed and immunoassay workflows (required).
- Strong analytical and documentation skills; experience maintaining accurate, detailed records.
- Experience with running, maintaining, and troubleshooting lab equipment.
- Desire and ability to work in a small interdisciplinary team to develop new technologies at a rapid pace.
Nice To Haves
- Experience with next generation DNA sequencing (instrumentation and analysis) and handling of tissues on flow cells is a plus.
- Familiarity with common enzymes that interact with DNA/RNA.
- Expertise in immunoassays (IHC, IF, ISH).
- Familiarity with microscopy-based readouts (particularly fluorescence).
- Working knowledge of fluorescence microscopy and imaging-based readouts is a strong plus.
- Familiarity with spatial biology platforms and workflows is a strong plus.
- Experience interpreting NGS-based transcriptomic and proteomic data is a strong asset.
Responsibilities
- Execute experiments to characterize antibody activity using immunofluorescence or IHC across diverse tissue types and conditions.
- Support antibody validation efforts using molecular biology techniques (e.g. SDS-PAGE), immunoassays, and/or G4X spatial biology assay across various tissue types.
- Day-to-day operation of the G4X sequencer.
- Manually prepare customer samples provided for spatial sequencing.
- Load consumables and program sequencing runs.
- Perform primary analysis of run data.
- Perform regular instrument maintenance.
- Daily run metrics and quality of sequencing performance review.
- Complete documentation to support data capture, forms, logbooks, and inventory batch records.
- Contribute to late-stage optimization of spatial biology workflows, ensuring readiness for product launch.
- Scheduling, usage forecasting and inventory management of consumables.
- Complete documentation to support logbooks, and inventory batch records.
Benefits
- equity as part of the compensation package
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Associate degree
