Senior Staff Scientist (Transgenic Animal and Genome Editing facility)

Cincinnati Children's•Orleans, MA

3d•Onsite

About The Position

The Transgenic Animal and Genome Editing facility (TAGE) is looking for an experienced scientist to assist in running the operations of the facility. This position includes 70% effort dedicated to TAGE service activities and 30% effort dedicated to research and technology development activities. The service portion involves supporting the daily operations of the TAGE facility, including project management, advanced gene-editing design and reporting, client meetings and communications, staff training, and troubleshooting. It also requires becoming proficient in all TAGE service procedures, particularly reagent preparation, embryo manipulation, superovulation, IVF, sperm cryopreservation, vector cloning, and genotyping, and performing wet-bench services as needed. The role also involves optimizing genome-editing techniques and methodologies in animals, iPSCs, and organoids, and implementing newly developed technologies into TAGE services, as well as contributing to grant applications and manuscript preparation for clients. The research portion is divided between externally funded research and TAGE-funded research, including technology development, testing new tools, promoting CRISPR clinical trials, manuscript and grant application preparation, and supervising postdocs and students. This position is critical for maintaining high-quality, innovative services and sustaining institutional competitiveness in genome engineering and animal/iPSC-based model development.

Requirements

PhD or MD
12+ years (after Doctorate) of work experience in a similar job or discipline.
Proven ability to understand and execute on difficult concepts.
Consistent or increasing trajectory of accomplishment in technical proficiency, scientific creativity, collaboration with others and independent thought.
Productivity as measured by continued Authorship on papers (i.e., lab, field of research and paper impact) – first authorship is weighted more heavily, or co-senior or co-corresponding.
Co-Investigator or writing own grant applications, writing majority of grant application with PI guidance and co-leaders.
Contributing as an investigator on the grant.
Increased responsibility in division and lab management, leadership within the lab, divisional responsibility.
Makes important contributions to scientific literature and conferences.

Nice To Haves

Achieved at least one first authorship paper in addition to operating as the lab leader.
Has multiple first or co-senior author paper and 1 or more Co-authorships.
A researcher of this distinction demonstrated continued productivity with multiple publications (minimum 10), this is not a threshold but an example of the numerous publications that a conversation can begin to be considered for the role; impact on papers matter.

Responsibilities

Initiates, directs and executes scientific research pertaining to a specific field of study.
Investigates the feasibility of applying a variety of scientific principles and concepts to solve problems.
Works on complex problems in which analysis of situations or data requires an in-depth evaluation of various factors, applying expertise and broad knowledge of principles, theories, and standard scientific/research protocols.
Creates formal networks with key decision makers.
Uses professional concepts in accordance with objectives to solve complex problems in creative and effective ways.
Exercises judgment within broadly defined practices and policies in selecting methods, techniques and evaluation criteria for obtaining results.
Responsible for lab administration (IRB/IACCUC/biosafety).
May oversee divisional or institutional core facilities, managing and/or providing training for instrumentation.
Research and improve current methods and evaluate innovative techniques.
Design and perform experiments and record data according to research protocol.
Independently reproduce, evaluate, research, and improve techniques currently used.
Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition.
Draft, write and edit scientific reports, papers, journal articles and abstracts.
Present at local, national and international scientific meetings.
Consistently Partners with PI to review papers for journals.
Lead and increased contribution to grant writing and applications.
Co-Investigator on grants.
Assist in preparing, writing, and maintaining fiscal budget.
Monitor expenditures and prepare capital expenditure requests.
Prepare, approve, and initiate check requests; track funding, maintain accurate balance and resolve any discrepancies.
Supervise junior lab members and trainees and may have direct reports.
Serves as the contact for resolution of complex issues, provide education, guidance and work direction.
May provide input and feedback to managers on hiring decisions, professional development and performance management.
Lead research programs or research teams within a lab and serve as leaders of divisional cores.
Interface with various departments and serves as expert to line of research.
Initiate and lead teaching and providing lectures and lab class.
Advises PI and other stakeholders as needed.
Train and supervise the work of other laboratory personnel as appropriate.
Maintain an integral role in the laboratory's meetings, presentations and publications.
Present information on research and laboratory work to others at laboratory meetings, journal clubs and seminars.
Demonstrate attendance and punctuality, ability to work independently & display initiative and dedication.
Maintain accurate and detailed records of all laboratory work and experiments.
Develop, set-up and verify new procedures in the laboratory.
Standardize and establish new published procedures; evaluate innovative techniques.
Develop new assays and new protocols; design formats.
Discuss relevant insights about experimental results with Director and provide useful recommendations and analysis.
Troubleshoot and correct erroneous results or problems with laboratory equipment.
Maintain and repair equipment; monitor proper use by personnel.
Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks.
Demonstrate performance at work, consistency in carrying out instructions, accuracy & attention to detail, achieving expected results & continuous improvement.
Acts independently with limited supervision to determine methods and procedures on new assignments.
Support the daily operation of the TAGE facility, including project management, advanced gene-editing design and reporting, client meetings and communications, staff training, and troubleshooting.
Become proficient in all TAGE service procedures, particularly reagent preparation, embryo manipulation, superovulation, IVF, sperm cryopreservation, vector cloning, and genotyping.
This position performs wet-bench services as needed.
Optimize genome-editing techniques and methodologies in animals, iPSCs, and organoids and implement newly developed technologies into TAGE services.
In addition, the position contributes to grant applications and manuscript preparation for clients.
This portion of the effort is divided between externally funded research and TAGE-funded research.
TAGE-funded research activities include technology development, testing newly developed tools in mice and iPSCs, promoting CRISPR clinical trials, manuscript and grant application preparation, and supervising postdocs and students in the lab.