Senior Distinguished Scientist for Transgenic Model and Technology

Sanofi•Cambridge, MA

10d•$178,500 - $257,833•Hybrid

About The Position

The Translational In Vivo Models (TIM) department within Sanofi's R&D is seeking an exceptional Senior Distinguished Scientist to lead our Transgenic Model & Technology (TMT) function globally. This strategic leadership role will drive innovation in genome engineering and genetically modified model development to accelerate drug discovery across all therapeutic divisions. As the Global Head of Transgenic Biology, you will ensure our organization remains at the forefront of technical developments in genome engineering, enabling breakthrough discoveries in immunology, immuno-inflammation, rare diseases, neuroscience, and oncology. You will serve as a key scientific advisor and strategic thinker, shaping the direction of in vivo and preclinical research programs while championing the integration of emerging technologies — including AI and digital platforms — into transgenic science. This role is based in Cambridge, MA and is primarily office/lab-based with some scope for flexible remote working.

Requirements

Ph.D. in Molecular Biology, Genetics, Developmental Biology, or a related discipline
Extensive post-doctoral or industry experience in mouse molecular genetics and transgenic animal model development
Demonstrated track record of scientific leadership in an academic or pharmaceutical/biotech research environment
Minimum of 5 years of demonstrated, hands-on experience performing this role.
Deep expertise in developing transgenic animal models, including engineering diverse genetic alleles using CRISPR/Cas9, Cas12, base editors, prime editors, and other advanced genome engineering systems
Comprehensive knowledge of both theoretical principles and practical methodologies required to lead a state-of-the-art transgenic facility
Strong foundation in molecular biology, mouse genetics, embryology, and reproductive technologies
Experience across multiple therapeutic areas (immunology, oncology, rare diseases, neuroscience preferred)
Proven strategic thinking and orientation with ability to align scientific capabilities with business objectives
Demonstrated success leading transversal teams and managing complex, multi-stakeholder projects across sites and functions
Established track record as a scientific thinker and advisor to in vivo and preclinical research programs
Experience identifying, evaluating, and implementing new technologies and innovations in a research setting
Familiarity with and application of AI and digital technologies in biological research, model design, and data analysis
Exceptional project management skills with ability to oversee multiple concurrent initiatives
Strong contract negotiation and vendor management capabilities
Excellent budget planning, financial management, and resource allocation skills
Outstanding interpersonal and communication skills (written and verbal) for effective collaboration across diverse, global stakeholders
Proven ability to work in matrix organizations and influence without direct authority
Self-motivated with demonstrated ability to lead and thrive in collaborative team environments
Comfortable managing competing priorities and adapting to dynamic research needs
Commitment to scientific excellence, integrity, and ethical research practices
Passion for mentoring and developing scientific talent
Candidates must be willing to travel as part of this position.

Responsibilities

Lead and advance state-of-the-art genome engineering techniques and mouse genetics applications for in vivo model development supporting discovery and developmental research
Apply personal expertise in transgenesis and CRISPR technology to devise and execute sophisticated experimental strategies for target validation, proof-of-concept, and efficacy studies
Identify, evaluate, and implement new technologies and innovations in transgenesis, CRISPR/Cas systems, and emerging genome engineering platforms
Serve as a strategic thinker and scientific advisor to research projects across therapeutic areas, providing expert guidance on in vivo and preclinical study design
Champion the integration of AI and digital technologies to enhance model design, data analysis, and predictive capabilities in transgenic research
Cover a broad scientific scope including immunology and immuno-inflammation, rare diseases, neuroscience, molecular and immune-oncology, and all areas of cell and molecular biology pertaining to immunology and immune-oncology
Demonstrate strategic thinking and orientation in aligning transgenic capabilities with organizational research priorities and long-term scientific goals
Lead and coordinate transversal teams and projects across multiple therapeutic divisions, sites, and external partners
Collaborate closely with the Head of Transgenic Division, drug discovery program leaders, cluster heads, and department heads to provide strategic scientific advice
Drive budget planning, forecasting, and financial management to optimize resource allocation and operational efficiency
Establish and maintain comprehensive project management frameworks ensuring full-service delivery from model design through study-ready animal production
Build and manage strategic relationships with model providers, CROs, and academic partners for development and delivery of genetically modified models
Negotiate and oversee license agreements and partnership contracts for model acquisition and technology access
Implement quality standards and continuous improvement initiatives to maintain operational excellence
Supervise, mentor, and develop staff members to build a high-performing team at the forefront of transgenic science
Participate in talent management decisions including hiring, promotions, performance evaluations, and organizational development
Foster a culture of scientific excellence, innovation, collaboration, and continuous learning