Senior Software Engineer

Tempus AI•Chicago, IL
•$110,000 - $160,000

About The Position

Tempus is seeking a Senior Software Engineer to advance its Genomics AI initiatives. The role involves analyzing and designing complex technical solutions, architecting robust systems, mentoring emerging talent, and building high-quality software. The engineer will apply full-stack, relational data, and algorithmic expertise; use modern AI development tools; integrate Generative AI APIs into user-facing applications; and embed agentic workflows into the product ecosystem. The position is part of a culture of small, autonomous teams where developers, designers, scientists, and product managers collaborate. The work contributes to solutions for cancer research and treatment, using an agile approach and modern architecture to support rapid innovation, quality, and scalability.

Requirements

  • At least 5 years of advanced TypeScript/JavaScript development experience, with deep understanding of language features and optimization techniques.
  • Extensive experience architecting and leading development with Node.js and NestJS.
  • Expert-level React development, including designing and implementing complex component systems.
  • Hands-on experience with GenAI coding tools and autonomous agents, such as Copilot, Cursor, or LLM APIs.
  • Experience or strong working knowledge integrating LLM APIs and GenAI technologies into production applications.
  • Advanced PostgreSQL skills, including query optimization, indexing strategies, and performance tuning.
  • Proven expertise implementing sophisticated Redis caching solutions for high-throughput systems.
  • Demonstrated success designing and implementing distributed microservice architectures.
  • Significant experience orchestrating infrastructure and applications on GCP, including CI/CD pipelines.
  • Mastery of enterprise-level design patterns and their practical application in large-scale, mission-critical systems.
  • At least 7 years of software development experience with a track record of technical leadership.
  • Ability to make high-impact architectural decisions that balance business needs with technical considerations.
  • History of successfully delivering complex projects in fast-paced environments.
  • Strong communication skills, including experience presenting technical solutions to diverse stakeholders.
  • Proven ability to drive cross-team technical initiatives and resolve complex engineering challenges.

Nice To Haves

  • Experience with search technologies such as Elasticsearch or OpenSearch.
  • Experience with containerization and orchestration tools such as Docker and Kubernetes.
  • Background in biotech, genomics, or precision medicine.
  • Success leading system migrations between cloud platforms, such as AWS to GCP.

Responsibilities

  • Lead the analysis and design of complex technical problems.
  • Architect robust systems and make high-impact architectural decisions.
  • Write high-quality code for full-stack applications and systems.
  • Integrate Generative AI APIs and technologies into production and user-facing applications.
  • Embed agentic workflows into the core product ecosystem and champion AI-assisted development practices.
  • Use AI coding tools and autonomous agents to accelerate development, refactor codebases, and generate unit and integration tests.
  • Mentor emerging talent and help teams adopt AI tools and workflows.
  • Drive cross-team technical initiatives and resolve complex engineering challenges.
  • Deliver complex projects in fast-paced environments and present technical solutions to diverse stakeholders.

Benefits

  • Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical benefits, and other benefits depending on the position.
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