Senior Scientist

Guidehouse•Baltimore, MD

2d•$130,000 - $216,000•Onsite

About The Position

We are looking for a Senior Scientist to support the operational and research objectives of the National Institute on Aging (NIA) Intramural Research Program by supporting genomic, genetics, single-cell sequencing, and spatial transcriptomics research activities. This is a full-time position located in Baltimore, MD. Provide on-site scientific expertise, laboratory support, and data analysis support for genomic and genetics experiments conducted by NIA research staff. Organize, validate, and process samples for microarray, next-generation sequencing, spatial transcriptomics, and single-cell sequencing experiments. Use advanced scientific knowledge and laboratory skills to resolve complex genetics and genomics issues, provide experimental guidance, and conduct pilot studies to develop and improve laboratory techniques. Maintain an accurate inventory of samples, reagents, and consumables through tracking systems and databases; obtain vendor quotes and assist with purchasing requests for laboratory supplies, services, and equipment. Perform operational troubleshooting, calibration, software updates, and maintenance of specialized laboratory instruments while ensuring compliance with laboratory safety procedures. Support the planning, execution, troubleshooting, and analysis of single-cell and spatial transcriptomics experiments utilizing platforms such as Chromium X and CytAssist. Acquire, maintain, and support specialized laboratory instrumentation and evaluate emerging technologies, software, and methodologies for potential implementation. Design and conduct complex scientific experiments requiring broad knowledge of molecular biology, genomics, transcriptomics, and related scientific principles. Provide technical support and scientific guidance to laboratory staff on research projects, experimental design, assay development, and data interpretation. Establish, train users on, and help manage Laboratory Information Management Systems (LIMS) and Electronic Laboratory Notebooks (ELN). Maintain, calibrate, troubleshoot, and train staff on laboratory instrumentation, equipment, and associated software applications. Manage scientific resources, including reagents, frozen cell stocks, biological samples, and research inventories. Conduct bioinformatics and statistical analyses and prepare data for abstracts, scientific reports, manuscripts, and presentations. Maintain accurate and detailed electronic laboratory notebooks and research documentation. Collaborate with Principal Investigators and research staff to prioritize instrument usage and optimize laboratory operations. Coordinate with IT personnel regarding software, data management, instrument connectivity, and technology-related issues. Prepare technical reports, manuscripts, abstracts, posters, oral presentations, and other scientific communications. Present research findings at laboratory meetings, scientific conferences, symposia, and national scientific meetings. Support data management and sharing initiatives, including organizing and uploading datasets to repositories such as GEO, SRA, and MassIVE. Provide mentoring, training, and technical guidance to fellows, postdoctoral researchers, students, biologists, and junior scientists. Support scientific collaborations, grant-related activities, laboratory organization initiatives, and research program development. Provide scientific guidance to management and laboratory leadership through literature reviews, technical evaluations, and recommendations for research activities and equipment purchases. Incumbent capture, no other candidates were considered due to incumbent candidate identified. They meet the labor category requirements provided by the customer.

Requirements

Ph.D. in Neuroscience, Biology, or a related scientific field.
Minimum of EIGHT (8) years of experience in genomics, genetics, molecular biology, and transcriptomics research.
Hands-on background supporting single-cell sequencing and spatial transcriptomics workflows.
Skilled in operating, maintaining, and troubleshooting specialized scientific instrumentation.
Background conducting bioinformatics and statistical analyses of genomic and transcriptomic datasets.
Proven ability to prepare scientific manuscripts, technical reports, presentations, and publication-quality figures.
Knowledge of laboratory inventory management, research documentation, and electronic records.
Proficiency with Microsoft Office Suite.
Ability to train, mentor, and support researchers and laboratory personnel.
Ability to maintain detailed electronic laboratory notebooks and research records.
Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

Nice To Haves

Familiarity with OLINK Explore Protein Biomarker Discovery platforms.
Knowledge of 10X Genomics single-cell sequencing technologies.
Strong oral and written communication skills.
Collaborative approach to working with multidisciplinary research teams.
Background supporting shared scientific core facilities or advanced research laboratories.
Ability to implement or administer Laboratory Information Management Systems (LIMS).
Skilled in managing scientific datasets and submissions to public repositories such as GEO, SRA, and MassIVE.
Exposure to Data Management and Sharing (DMS) initiatives.
Record of peer-reviewed publications and scientific presentations.
Mentoring background with fellows, postdoctoral researchers, students, or junior scientists.
Ability to evaluate and implement emerging laboratory technologies and research methodologies.

Responsibilities

Provide on-site scientific expertise, laboratory support, and data analysis support for genomic and genetics experiments conducted by NIA research staff.
Organize, validate, and process samples for microarray, next-generation sequencing, spatial transcriptomics, and single-cell sequencing experiments.
Use advanced scientific knowledge and laboratory skills to resolve complex genetics and genomics issues, provide experimental guidance, and conduct pilot studies to develop and improve laboratory techniques.
Maintain an accurate inventory of samples, reagents, and consumables through tracking systems and databases; obtain vendor quotes and assist with purchasing requests for laboratory supplies, services, and equipment.
Perform operational troubleshooting, calibration, software updates, and maintenance of specialized laboratory instruments while ensuring compliance with laboratory safety procedures.
Support the planning, execution, troubleshooting, and analysis of single-cell and spatial transcriptomics experiments utilizing platforms such as Chromium X and CytAssist.
Acquire, maintain, and support specialized laboratory instrumentation and evaluate emerging technologies, software, and methodologies for potential implementation.
Design and conduct complex scientific experiments requiring broad knowledge of molecular biology, genomics, transcriptomics, and related scientific principles.
Provide technical support and scientific guidance to laboratory staff on research projects, experimental design, assay development, and data interpretation.
Establish, train users on, and help manage Laboratory Information Management Systems (LIMS) and Electronic Laboratory Notebooks (ELN).
Maintain, calibrate, troubleshoot, and train staff on laboratory instrumentation, equipment, and associated software applications.
Manage scientific resources, including reagents, frozen cell stocks, biological samples, and research inventories.
Conduct bioinformatics and statistical analyses and prepare data for abstracts, scientific reports, manuscripts, and presentations.
Maintain accurate and detailed electronic laboratory notebooks and research documentation.
Collaborate with Principal Investigators and research staff to prioritize instrument usage and optimize laboratory operations.
Coordinate with IT personnel regarding software, data management, instrument connectivity, and technology-related issues.
Prepare technical reports, manuscripts, abstracts, posters, oral presentations, and other scientific communications.
Present research findings at laboratory meetings, scientific conferences, symposia, and national scientific meetings.
Support data management and sharing initiatives, including organizing and uploading datasets to repositories such as GEO, SRA, and MassIVE.
Provide mentoring, training, and technical guidance to fellows, postdoctoral researchers, students, biologists, and junior scientists.
Support scientific collaborations, grant-related activities, laboratory organization initiatives, and research program development.
Provide scientific guidance to management and laboratory leadership through literature reviews, technical evaluations, and recommendations for research activities and equipment purchases.

Benefits

Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach
Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
Position may be eligible for a discretionary variable incentive bonus