Senior Scientist
About The Position
The Senior Scientist will join the Analytical R&D Department at MilliporeSigma at our Life Sciences R&D facility in St. Louis. In this role, you will be part of an active, multidisciplinary group of scientists dedicated to providing high level analytical support to product development scientists in R&D, manufacturing groups, and special project teams. You will be expected to lead development of LC-MS assays for the quantitation of proteins in complex mixtures. Additionally, you will perform advanced characterization of large biomolecules including monoclonal antibodies, multi-specifics, and antibody drug conjugates.
Requirements
- BS in Chemistry or related field plus 5-7+ years of experience with demonstrated hands-on proficiency with advanced instrumentation, with high resolution and/or triple quadrupole LC-MS platforms OR a master’s degree with 3-5+ years of stated above experience, OR a PhD with 0-1+ years of stated above experience
- Advanced experience with a variety of enzymatic and chemical methods of sample preparation for large biomolecule LC-MS, such as digestion, enrichment, depletion, and labelling or related
- Experience working and communicating effectively both independently and in a team-oriented environment
- External applicants must be eligible to work in the US.
Nice To Haves
- Experience in absolute quantitation of proteins and antibodies by Multiple Reaction Monitoring (MRM) and/or Parallel Reaction Monitoring (PRM) mass spectrometry
- Experience in bottom up, middle up/down, and/or top-down protein LC-MS workflows
- Experience with specific workflows such as non-reduced and reduced intact mass analysis, peptide mapping, disulfide mapping, Post-Translational Modifications (PTM) characterization, glycosylation profiling, and/or free thiol analysis
- Experience with bioinformatics related to the quantitation and characterization of large biomolecules such as UNIFI, BioPharma Finder, Mascot, and Scaffold
- Proficiency in a variety of instrument platforms such as Thermo, Sciex, Waters, and Agilent mass spectrometers
- Hands-on experience with MALDI-MS
Responsibilities
- Lead development of LC-MS assays for the quantitation of proteins in complex mixtures.
- Perform advanced characterization of large biomolecules including monoclonal antibodies, multi-specifics, and antibody drug conjugates.
Benefits
- health insurance
- paid time off (PTO)
- retirement contributions
- other perquisites
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What This Job Offers
Job Type
Full-time
Career Level
Senior
