Senior Scientist – In Vitro Neuroimmunology- Boston, MA
About The Position
The Neuroimmunology team in Boston is seeking an independent, motivated scientist with expertise in cell biology, immunology, and/or neuroscience to validate and advance novel neuroimmune targets for CNS diseases. The Senior Scientist will establish assay systems, shape experimental strategies, and deliver datasets and analyses that inform pipeline programs. This is a lab-based role focused on designing and executing in vitro experiments, including establishing and characterizing cell-based model systems, particularly induced pluripotent stem cell (iPSC) models. The role provides scientific leadership for established and emerging therapeutic discovery programs through advanced in vitro disease modeling and translational research. The scientist is expected to work independently, collaborate proactively across disciplines, and participate in constructive scientific dialogue. The position requires 90% of time in the lab.
Requirements
- Ph.D. in Molecular Cell Biology, Neuroscience, Pharmacology, Biology, or a related field, with post-doctoral or industry experience.
- Ability to work independently and thrive in a team environment.
- Extensive experience with CNS iPSC cell culture, including construction of complex in vitro tri-culture models.
- Experience culturing immune cell lines, primary murine microglia, and iPSC-derived microglia.
- Recognized scientific expertise in designing, executing, and interpreting complex in vitro and translational studies, and generating mechanistic insights to advance target validation, therapeutic strategy, and drug discovery decisions.
- Strong data analysis skills and willingness to use AI tools for quality control of small and large datasets.
- Experience with standard laboratory cell culture procedures, including DNA transfection, viral delivery, and immunocytochemistry.
- Ability to independently perform tissue and cellular protein/RNA preparations, quantitative PCR, western blots, and ELISAs.
- Excellent oral and written communication skills, including preparing study reports and presentations and contributing to manuscripts for peer-reviewed journals.
- Demonstrated scientific innovation, thought leadership, and problem-solving, evidenced by impactful publications, scientific presentations, patents, technology development, or contributions to drug discovery programs.
- Ability to spend 90% of working time in the lab.
Nice To Haves
- Primary neuronal or astrocyte culture experience.
- Experience applying high-content imaging to cell-based assays.
- Experience with multiple therapeutic modalities, including small molecules, antibodies, peptides, or siRNA.
- Experience in neuroscience and pharmaceutical research.
- Experience with Alzheimer’s, Parkinson’s, or ALS disease.
Responsibilities
- Develop, execute, and troubleshoot cell-based assays, protocols, and analysis methods.
- Design and lead complex experimental programs, interpret multidimensional datasets, and communicate scientific recommendations that inform project strategy and research decisions.
- Isolate and characterize tissues, whole blood, PBMCs, and iPSC-derived cell populations using immunocytochemistry, DNA/RNA isolation, PCR, NanoString, RNA-seq, and other molecular biology techniques.
- Provide scientific oversight of external research activities and collaborations, including study design, protocol review, data interpretation, and integration of external findings into program decisions.
- Communicate data clearly and concisely to appropriate teams and stakeholders, both orally and in writing.
- Integrate emerging scientific literature, competitive intelligence, and technological advances to shape internal research direction and strategy.
- Contribute to scientific innovation by developing novel model systems, evaluating emerging technologies, publishing research findings, and presenting results to internal and external scientific audiences.
- Establish and characterize in vitro cell-based disease models, with a focus on iPSC models.
- Apply advanced in vitro disease modeling and translational research approaches to support therapeutic discovery programs.
Benefits
- Medical, dental, and vision healthcare benefits and other insurance benefits for employees and their families.
- Retirement benefits, including a 401(k).
- Paid holidays, vacation, compassionate leave, and sick days.
- Eligible for an annual bonus and long-term incentive, if applicable.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
