Senior Scientist I, Lentiviral Engineering & In Vitro Assay Development
About The Position
AbbVie is seeking a Senior Scientist to join its Genetic Medicine in vivo CAR-T group within the Biotherapeutics and Genetic Medicine department. The role focuses on designing and executing experimental approaches to address scientific challenges related to in vivo lentiviral delivery platforms. The successful candidate will drive scientific innovation, introduce methods and techniques, and collaborate across functions to advance novel in vivo CAR-T therapies. The Senior Scientist will lead in vitro research and partner with the in vivo pharmacology group on in vivo studies. The position also involves engineering lentiviral vectors and fusion protein receptors, overseeing lentiviral production, advancing pipeline programs from discovery through translational development, analyzing multidisciplinary data, communicating findings, contributing to publications and patent applications, and mentoring junior scientists. Work is performed independently with minimal supervision, with appropriate material handling in a BSL-2 environment.
Requirements
- BS, MS, or PhD in immunology, oncology, cell biology, molecular biology, biochemistry, or a related field, with typically 10+ years of experience for a BS, 8+ years for an MS, or 0–3+ years for a PhD.
- Expertise in mammalian primary cell and cell line culture, including primary T cells, PBMCs, whole blood, and suspension and adherent cell lines.
- Expertise in multi-color flow cytometry, including panel design, acquisition, and analysis.
- Expertise in immunological assays such as ELISA, Luminex, and cytotoxicity assays.
- Ability to develop, troubleshoot, and refine assays to improve sensitivity, reproducibility, and throughput.
- Self-motivated and able to thrive in a fast-paced, collaborative team environment.
- Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.
- Detail-oriented, with a commitment to delivering high-quality results.
Nice To Haves
- Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows.
- Experience with lentiviral vector design, production, and analytical characterization, such as titering, copy number analysis, and transduction efficiency assessment.
- Experience evaluating vector biodistribution, transduction specificity, or safety-related parameters.
- Experience in CAR-T cell therapy and/or in vivo targeted delivery.
Responsibilities
- Lead research efforts and design and execute in vitro studies, including multi-color flow cytometry, ELISA, luciferase, and ddPCR assays; collaborate with the in vivo pharmacology group on in vivo studies.
- Design and engineer lentiviral vectors and fusion protein receptors, and oversee lentiviral production using internal capabilities and external CRO partnerships.
- Partner with cross-functional and therapeutic area teams to advance lentiviral-based in vivo CAR-T programs from early discovery through translational development.
- Uphold company culture, teamwork, and safety standards, including appropriate handling of materials in a BSL-2 environment.
- Work independently with minimal supervision while maintaining productivity, efficiency, and scientific rigor.
- Maintain comprehensive, well-documented records in an Electronic Lab Notebook (ELN).
- Analyze and interpret multidisciplinary data to draw actionable conclusions, identify risks, and guide future experimental directions.
- Collaborate and communicate results with stakeholders and cross-functional teams throughout the organization.
- Contribute as a primary author to scientific publications and presentations, and/or as a primary inventor of patent applications.
- Demonstrate a proactive, solutions-oriented mindset and take ownership of additional responsibilities as needed.
- Mentor and support junior scientists.
Benefits
- Paid time off, including vacation, holidays, and sick leave.
- Medical, dental, and vision insurance for eligible employees.
- 401(k) for eligible employees.
- Eligibility to participate in short-term incentive programs.
- Opportunities for professional growth.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
