Senior Scientist

UVA Health•Charlottesville, VA

11d•Onsite

About The Position

The W.M. Keck Biomedical Mass Spectrometry Lab, part of the Biomolecular Analysis Facility Core at the University of Virginia, is seeking a Senior Scientist to expand its work in proteomics and metabolomics. This role utilizes state-of-the-art instruments to support institutional research in areas such as basic science, the Cancer Center, and clinical projects. The position requires expertise and hands-on experience in biomedical science, with a focus on mass spectrometry, chromatography, and protein/small molecule chemistry. The Senior Scientist will support the director through sample preparation, operation and maintenance of advanced mass spectrometers (Orbitrap ID-X, Vanquish Neo, Orbitrap Astral Zoom, Evosep Eno), and data analysis using advanced software packages (Proteome Discoverer, Compound Discoverer, Scaffold, etc.). This work will contribute to institutional goals in proteomic and metabolomic profiling and translational research. The ideal candidate will possess excellent communication and team support skills, be highly motivated, and capable of independent experimental design and execution. A high priority is placed on customer support for researchers within the institution. Projects will involve applying existing techniques to address biological challenges and developing new technologies in proteomics and metabolomics.

Requirements

Doctoral degree, preferably a Ph.D. in Mass Spectrometry or in a very closely related field.
Prior experience in qualitative and quantitative proteomics and metabolomics technology and nano-liquid chromatography and mass spectrometry (LC-MS; on Orbitrap Fusion, Orbitrap Astral, and/or Orbitrap ID-X).
Familiarity with the entire metabolomics and/or proteomics pipeline (including sample preparation, LC and MS operation, and data analysis).
Demonstrated scientific productivity.
Excellent oral and written communication skills.
Attention to detail and ability to learn new technologies, flexibility and time management skills.
5+ years’ direct experience in mass spectrometry or a MS in very closely related field and 10+ years’ experience in proteomics or metabolomics.
Experience with Proteome/Compound Discoverer, Scaffold, MS Dial, MetaboAnalyst, etc.
Advanced knowledge of Thermo mass spectrometers – operation and maintenance.

Nice To Haves

Proven record of excellent communication and team support.
Highly motivated and able to work independently when designing and executing experiments.
Customer support of researchers within the institution is a high priority.

Responsibilities

Sample preparation
Operation and maintenance of advanced mass spectrometers (Orbitrap ID-X – Vanquish Neo and Orbitrap Astral Zoom – Evosep Eno)
Data analysis using advanced software packages (Proteome Discoverer, Compound Discoverer, Scaffold, etc.)
Manage multiple projects between multiple laboratories
Conduct independent projects
Collaborate across multiple disciplines and engage investigators in project design, execution and data analysis
Publication and grant writing