Senior Scientist

Legend Biotech US • Philadelphia, PA

2d • Hybrid

About The Position

Legend Biotech is seeking a Senior Scientist as part of the R&D Leadership Development Program based in Philadelphia, PA. Role Overview The Early Career Leadership Program at Legend Biotech is a strategic, enterprise-focused development experience designed to accelerate the growth of high-potential professionals early in their careers. Rooted in our commitment to cultivating enterprise-minded, value-driven leaders, this program provides structured rotational exposure, executive mentorship, and real-time business impact across scientific, operational, and corporate functions. The R&D Hi-Po Leadership Development Program is a project-based, enterprise leadership accelerator designed for high-potential PhD graduates who aspire to shape the future of cell and gene therapy. Over 2.5–3 years, participants will lead 3-4 high-impact, 8-12-month strategic projects across R&D, Preclinical Development, Technical Development, Business Development and Regulatory Affairs. This immersive experience is built to cultivate scientific leaders capable of translating discoveries into development, advancing complex pipeline programs, and influencing cross-functional strategy. Participants will gain enterprise exposure, executive mentorship, and access to a formal Annual Leadership Development Series focused on strategic thinking, regulatory and clinical acumen, and senior leadership readiness. Join us in advancing the frontiers of cell and gene therapy—where your discoveries can redefine treatment paradigms and transform patient outcomes worldwide We are seeking a highly motivated Senior Scientist to join our growing In Vivo CAR-T Cell Therapy team. The successful candidate will contribute to the development of our in vivo CAR-T platform and pipeline by leveraging expertise in cellular immunotherapy, virology, and immunology. This role requires scientific excellence, strong collaboration skills, and the ability to drive projects in a fast-paced environment. Join us in redefining what’s possible and build a career where your growth and patient impact go hand in hand.

Requirements

• PhD in Immunology or a related discipline.
• Minimum of 3 years of experience in cell and gene therapy research, with experience in CAR-T cell therapy strongly preferred.
• Strong hands-on experience with cellular immunology, viral vector technologies, and functional assay development.
• Demonstrated scientific productivity through publications, patents, or equivalent achievements.
• Strong experimental design, data analysis, troubleshooting, and problem-solving skills.
• Excellent verbal and written communication skills, with the ability to effectively present complex scientific concepts to diverse audiences.
• Passion for advancing next-generation cell and gene therapies.
• Strong sense of scientific ownership, accountability, and attention to detail.
• Commitment to continuous learning and staying current with emerging scientific and industry developments.
• Strong team-oriented mindset with a willingness to mentor and support colleagues.
• Ability to thrive in a dynamic, fast-paced, and highly collaborative environment.

Responsibilities

• Design and execute research projects to drive innovation of cell and gene therapy platforms and advance pipeline development.
• Develop and optimize assays, including but not limited to lentiviral vector production and titration, advanced multi-parameter flow cytometry, Incucyte, ELISA, cytotoxicity assays, and PCR-based analyses.
• Conduct in vitro and in vivo studies to evaluate potency, function, and safety of drug candidates.
• Collaborate closely with cross-functional teams to evaluate novel designs and generate robust, reproducible, and data-driven conclusions.
• Analyze, interpret, and document experimental results in a timely and highly organized manner, maintaining accurate scientific records and ensuring data integrity.
• Contribute to scientific strategy, experimental planning, and technology innovation to support pipeline advancement.

Benefits

• Medical, dental, and vision insurance
• 401(k) retirement plan with a company match that vests fully on day one
• Eight (8) weeks of paid parental leave after just three (3) months of employment
• Paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
• Flexible spending and health savings accounts
• Life and AD&D insurance
• Short- and long-term disability coverage
• Legal assistance
• Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
• Voluntary commuter benefits
• Family planning and care resources
• Well-being initiatives
• Peer-to-peer recognition programs

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree