Senior Scientist, Vector Attribute Sciences

Bristol Myers Squibb • Seattle, WA

22h • $124,190 - $150,483

About The Position

The Senior Scientist will serve as the technical leader and subject matter expert for AAV and LVV analytical methods within Cell Therapy Analytical Development's Attribute Science group. Grounded in virology, the role leads development, troubleshooting, and continuous improvement of methods used to characterize viral vector drug substances, while mentoring scientists and helping build CTAD's viral vector analytical expertise for next-generation cell therapy modalities.

The role collaborates with process development, manufacturing, CMC, research, team leadership, and external collaborators. It contributes to vector Critical Quality Attribute strategy, method lifecycle management, investigations, technical documentation, and regulatory submissions.

Requirements

• Ph.D. in Virology, Molecular Biology, Immunology, or a related discipline with relevant industry experience; alternatively, an M.S. or B.S. with proportionally greater hands-on experience in viral vector analytical development.
• Solid foundation in virology, including AAV and/or lentiviral biology, vector genome structure, capsid or envelope biology, and vector-host interactions.
• Demonstrated ability to independently troubleshoot analytical methods such as qPCR/ddPCR, ELISA, potency or functional assays, and capsid or particle characterization, from root-cause diagnosis through resolution.
• Ability to act as a technical resource and informal leader, mentor colleagues, and drive consistent, high-quality execution.
• Hands-on experience developing and qualifying analytical methods for viral (AAV/LVV) gene delivery platforms in a regulated environment.
• Collaborative experience partnering across process development, manufacturing, and CMC.
• Experience contributing to CQA strategy, technical reports, and regulatory submission documents.
• Excellent verbal, written, and oral communication skills, with the ability to explain complex technical concepts to varied audiences.

Nice To Haves

• Experience with non-viral platforms such as RNP, RNA, or LNP.
• Experience with automation and high-throughput analytical solutions.

Responsibilities

• Set technical direction for AAV and LVV analytical method selection, development, and lifecycle management.
• Troubleshoot and resolve complex method and instrument performance issues using mechanistic understanding of viral vector biology and assay chemistry.
• Develop, qualify, and continuously improve methods to characterize AAV and LVV drug substances, including vector identity, purity, potency, and functional integrity.
• Mentor and coach scientists and associate scientists in viral vector method execution and troubleshooting.
• Partner with process development, manufacturing, and CMC to diagnose and resolve method-related deviations and investigations.
• Lead identification and definition of Critical Quality Attributes for vector drug substances.
• Author and review SOPs, technical reports, and regulatory submission documents, including S.3.1 sections.
• Present technical strategy and findings to team leadership, cross-functional partners, and external collaborators.
• Represent viral vector analytical expertise in early platform assessment and program-level discussions.
• Monitor emerging viral vector analytical technologies and virology literature and bring relevant approaches and best practices into the team.

Benefits

• Comprehensive benefit plans, including wellbeing support, retirement and financial protection benefits, and medical, dental, vision, life, and disability insurance offerings.
• Flexible Time Off without a set accrual limit for eligible U.S.-based exempt employees, subject to manager approval.
• 11 paid company holidays each year.
• For specified non-exempt, RayzeBio, and Puerto Rico employees: 160 hours of paid vacation annually for new hires, subject to manager approval, 11 paid company holidays, and 3 optional holidays.
• Depending on eligibility, additional time-off benefits may include paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees may receive an annual Global Shutdown between Christmas Day and New Year's Day.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior