Senior Scientist - Target Discovery & Validation – Induced Proximity Platform (IPP)
About The Position
Join Amgen’s Mission of Serving Patients. Amgen is seeking a passionate and innovative Scientist to join the Induced Proximity Platform team in Burnaby. This role is at the frontier of discovery biology, combining induced proximity technologies to uncover novel therapeutic targets across Amgen’s key therapeutic areas including Oncology, Inflammation, and Cardiometabolic diseases. The successful candidate will lead and support cell surface target discovery, validation, and functionalization efforts by developing and applying innovative in vitro assays, proteomics workflows, and flow cytometry based approaches. This role will contribute to large molecule multispecific therapeutic development through target validation, model development, and MOA studies, while collaborating across multidisciplinary teams to analyze data, communicate findings, and maintain high-quality experimental documentation.
Requirements
- Doctorate degree or Master’s degree and 2 years of relevant scientific experience or Bachelor’s degree and 4 years of relevant scientific experience.
Nice To Haves
- Expertise in proximity labeling proteomics platforms and target validation using flow cytometry, biochemical and imaging-based techniques.
- Experience in cell line generation and overexpression systems (e.g., lentiviral delivery).
- Experience with antibody therapeutics and functional validation of targets using cell-based assays.
- Hands on experience with cloning, expression and purification analysis is a plus.
- Familiarity with high-throughput automation platforms (e.g., Agilent Bravo), high-content imaging platforms and analysis software.
- Track record of scientific innovation, publications, and/or conference presentations.
- Demonstrated ability to work collaboratively in fast-paced, multidisciplinary teams.
- Excellent verbal, written, and organizational skills.
Responsibilities
- Design, implement, and execute complex experimental workflows to profile and validate cell surface proteins.
- Lead and support cell surface-based target discovery and validation projects using in vitro models (cell lines, primary cells, tissues, etc.).
- Apply proximity labeling, cell surface enrichment, and related proteomics efforts for target validation and nomination studies.
- Support target functionalization efforts toward developing multispecific antibody therapeutics, and perform efficacy, mechanism of action (MoA) and drug response studies for these therapeutics.
- Use cutting-edge software tools and collaborate with bioinformatics to analyze and interpret target discovery proteomics datasets.
- Collaborate across multidisciplinary teams to drive integrated target discovery, validation and functionalization efforts.
- Present findings internally and externally through team meetings, conferences, and peer-reviewed publications.
- Maintain detailed electronic lab notebooks and experimental records.
Benefits
- Competitive and comprehensive total compensation programs aligned with local industry standards.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
