Scientist, Target Discovery & Validation

Alnylam Pharmaceuticals•Cambridge, MA

5d•Onsite

About The Position

The Target Discovery and Validation group at Alnylam is seeking a motivated and knowledgeable Scientist in the early target space. This is an exciting time at Alnylam, with our liver platform well validated and rapidly expanding to more and more tissues and indications. The responsibilities of this role will include identification of novel drug targets in a variety of indications and tissues, and leadership of preclinical proof of concept studies to validate target feasibility. We are looking for a curious quick learner, who is able to quickly adapt to new areas of interest. The candidate will join a multidisciplinary group that identifies, validates, and develops drug candidates from idea to clinic. This position is onsite and will be primarily located in Cambridge, MA.

Requirements

PhD in biology or biomedical sciences-related field.
Solid organizational skills and ability to multitask are a must.
The successful candidate will have strong interpersonal and communication skills, track record of working on teams, interest in learning new biology and passion for lab work.

Nice To Haves

Post doc or 1-2 years of experience strongly preferred.
Strong publication record.
Existing focus on disease biology and prior experience with mammalian disease models is also preferred.
Experience in using human genetics to support biological mechanisms is a plus.

Responsibilities

Work closely with Alnylam’s human genetics, multi-omics, platform and clinical teams to identify promising novel targets.
Contribute to Alnylam’s target identification efforts that are based on human genetics, literature, academic collaborations, genomic approaches, etc.
Design and execute proof of concept experiments in animal and in vitro disease models.
Design studies, coordinate activities, and lead from the bench.
Oversee lead discovery activities for the selection of drug candidates for further development.
Develop assays to monitor target engagement/pharmacodynamic responses.
Manage relationships with contract research organizations (CROs) and/or academic collaborators, including development of research plans and data analysis.
Mentor junior scientists.
Collaborate and communicate results with key stakeholders throughout organization.