Senior Scientist - Experimental Protein Design for Target Discovery

Amgen • South San Francisco, CA

2d

About The Position

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Requirements

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc experience on Protein Design] OR Master’s degree and 3 years of Protein Engineering experience OR Bachelor’s degree and 5 years of Protein Engineering experience

Nice To Haves

• Demonstrated experience in the expression, purification, and biochemical or biophysical characterization of engineered proteins, such as antibodies, minibinders, or other designed scaffolds in a high-throughput or library-based manner.
• Experience with different expression hosts (cell-free expression, E. coli, and mammalian) is a plus.
• Experience in binder hit validation using flow cytometry and SPR, and in developing cellular-based assays for functional characterization.
• Experience working with designed binders or protein–protein interaction engineering, with working knowledge of protein structure–function relationships.
• Experience and interest in collaborating with computational protein design teams and translating in silico designs into experimentally testable reagents.
• Experience with automation platforms and high-throughput experimentation is a plus.
• Experience supporting phenotypic screening, receptor biology, or early target characterization is a plus.
• Strong organizational and communication skills, with the ability to work effectively in cross-functional discovery teams.

Responsibilities

• Build and lead high-throughput platforms for binder generation, translating computational protein designs into experimentally validated minibinders and antibodies across diverse pre-discovery targets.
• Production, experimental validation, and characterization of computationally designed de novo binders.
• Create scalable binder libraries for multiplexed phenotypic screening.
• Develop multispecific tool molecules to interrogate novel biology.
• Provide tool reagents for early-stage target characterization.
• Integrate computational design with rapid experimental validation to advance high-throughput binder discovery strategies and drive innovative approaches to probe emerging targets and accelerate early-stage therapeutic discovery.
• Translate computational protein designs into experimentally testable minibinders and antibodies across multiple targets in parallel.
• Lead high-throughput workflows for binder expression, purification, and characterization, including development of cellular assays for binder–target evaluation.
• Partner with molecular biology teams to establish construct generation and binder library production workflows, enabling both individual binder characterization and scalable pooled library screening.
• Develop strategies to format de novo binders into appropriate modalities (e.g., multispecifics) to enable testing of biological hypotheses.
• Analyze and interpret experimental data to guide iterative design-build-test cycles.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree