Principal Scientist – Antibody Discovery/Protein Design

EVOLVEIMMUNE THERAPEUTICS INC•Branford, CT

22h•Onsite

About The Position

EvolveImmune Therapeutics is seeking a Principal Scientist to join their Biotherapeutics group. This role focuses on designing and advancing first-in-class immune-engaging biologics. The ideal candidate will be a protein engineer with expertise in computational protein design, experimental experience in protein discovery and optimization using antibody display technologies, and an interest in advancing drug candidates towards first-in-patient evaluation. This position offers significant scientific challenge and the opportunity to directly impact the future of cancer immunotherapy.

Requirements

PhD in biochemistry, computational biology, or structural biology, and postdoctoral fellowship in a related field
5+ years of antibody and biotherapeutic engineering industry experience
Foundation in protein design and molecular modeling using AI/ML
Yeast or alternative antibody display technologies experience from design through screening
Expertise in bispecific or multispecific protein design, expression, purification, and biophysical characterization
Strong communication, data interpretation, and cross-functional collaboration skills

Responsibilities

Design and optimize novel antibody-based multispecifics targeting domains using AI/ML-model-based de novo sequence discovery
Lead antibody engineering and antibody display-based screening from idea to experimental execution including screening, hit prioritization, and initial characterization.
Optimize developability in lead optimization through computational and biophysical insights
Expand company computational protein design tools and capabilities
Collaborate across functional teams to support candidate selection and preclinical development
Present findings in a clear, compelling way to multidisciplinary teams
Mentor junior scientists and help shape our growing discovery efforts