Senior Scientist, siRNA Synthesis

AbbVie • Worcester, MA

6h

About The Position

The Biotherapeutic and Genetic Medicine (BGM) department at AbbVie is seeking a motivated Principal Research Scientist I to join the growing siRNA team. In this role, you will work with the genetic medicine teams to establish siRNA synthesis, purification, and analytical capabilities. This individual will serve as a subject matter expert in oligonucleotide synthesis and purification, with responsibility for generating high-quality siRNA materials for advancing genetic medicine studies.

Requirements

• BS, MS, or PhD in Chemistry, Chemical Biology, Biochemistry, or a related field with typically 0-4+ years (PhD), 8-10+ years (MS), or 10-12+ years (BS) of relevant biotech or pharmaceutical industry experience.
• Proven track record in gram-scale oligonucleotide synthesis using oligonucleotide synthesizers, as well as development of oligonucleotide purification methods using liquid chromatography systems.
• Strong knowledge of oligonucleotide chemistry and RNA chemistry.
• Experience working cross-functionally with analytical and conjugation teams.
• Demonstrated ability to independently solve complex technical problems and drive projects forward.
• Excellent communication, collaboration, and organizational skills.
• Strong track record of presenting scientific data to internal and external stakeholders.

Responsibilities

• Lead the siRNA synthesis platform to support various stages of siRNA studies.
• Perform solid-phase oligonucleotide synthesis, deprotection, purification, and desalting of siRNA.
• Troubleshoot synthesis and purification challenges to improve yield, purity, and scalability.
• Work closely with the siRNA analytical colleagues to support characterization, data interpretation, and quality assessment of siRNA materials.
• Collaborate closely with the conjugation team to advance siRNA conjugate development and support platform and project objectives.
• Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
• Track emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.
• Mentor junior scientists and contribute to a collaborative, high-performing team environment.

Benefits

• paid time off (vacation, holidays, sick)
• medical/dental/vision insurance
• 401(k)
• short-term incentive programs
• long-term incentive programs

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree