Senior Scientist, siRNA Synthesis
AbbVie•Worcester, MA
•$109,500 - $208,500•Onsite
About The Position
The Biotherapeutic and Genetic Medicine (BGM) department at AbbVie is seeking a motivated Principal Research Scientist I to join the growing siRNA team. In this role, you will work with the genetic medicine teams to establish siRNA synthesis, purification, and analytical capabilities. This individual will serve as a subject matter expert in oligonucleotide synthesis and purification, with responsibility for generating high-quality siRNA materials for advancing genetic medicine studies.
Requirements
- BS, MS, or PhD in Chemistry, Chemical Biology, Biochemistry, or a related field with typically 0-4+ years (PhD), 8-10+ years (MS), or 10-12+ years (BS) of relevant biotech or pharmaceutical industry experience.
- Proven track record in gram-scale oligonucleotide synthesis using oligonucleotide synthesizers, as well as development of oligonucleotide purification methods using liquid chromatography systems.
- Strong knowledge of oligonucleotide chemistry and RNA chemistry.
- Experience working cross-functionally with analytical and conjugation teams.
- Demonstrated ability to independently solve complex technical problems and drive projects forward.
- Excellent communication, collaboration, and organizational skills.
- Strong track record of presenting scientific data to internal and external stakeholders.
Responsibilities
- Lead the siRNA synthesis platform to support various stages of siRNA studies.
- Perform solid-phase oligonucleotide synthesis, deprotection, purification, and desalting of siRNA.
- Troubleshoot synthesis and purification challenges to improve yield, purity, and scalability.
- Work closely with the siRNA analytical colleagues to support characterization, data interpretation, and quality assessment of siRNA materials.
- Collaborate closely with the conjugation team to advance siRNA conjugate development and support platform and project objectives.
- Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
- Track emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.
- Mentor junior scientists and contribute to a collaborative, high-performing team environment.
Benefits
- paid time off (vacation, holidays, sick)
- medical/dental/vision insurance
- 401(k)
- short-term incentive programs
- long-term incentive programs
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
