Senior Scientist, Reagent/Assay Development

Roche•Santa Clara, CA

3d•$99,000 - $133,400•Onsite

About The Position

The Senior Scientist, Reagent/Assay Development will contribute to the development and optimization of reagents and assays for next-generation sequencing (NGS) applications. This role combines hands-on laboratory work, experimental design, data analysis, and troubleshooting to improve reagent and workflow performance, robustness, and manufacturability. As a scientist, you will work closely with cross-functional teams, including automation, software, engineering, quality, and operations, to support product development and transfer to manufacturing.

Requirements

Bachelor’s degree in Biological/Life Sciences, Chemistry, Biochemistry, or related field
5 years of experience with NGS workflows
Reagent development
Assay development in a product-development environment
Strong hands-on experience with NGS and molecular biology techniques.
Experience with laboratory automation and automated instrumentation, including workflow development, optimization, and troubleshooting.
Proficiency in Python or other relevant programming languages for data analysis, visualization, and/or automation.
Strong skills in experimental design, data analysis, troubleshooting, and problem-solving.

Nice To Haves

Ph.D. in molecular biology, biochemistry, chemistry, genetics, bioengineering, or a related field
0-3 years of NGS-related research or industry experience
Familiarity with Design of Experiments (DOE), statistical analysis, and process optimization is a plus.
Experience collaborating with automation, software, and mechanical engineering teams is a plus.

Responsibilities

Conducting experiments to evaluate and optimize the performance of reagents, including assessing their stability, formulation, and manufacturing tolerances.
Designing, developing, and validating assays to assess the quality of both incoming and manufactured reagents.
Contributing to the establishment of manufacturing processes for reagents and transferring these processes to operations.
Analyzing experimental data, forming conclusions and suggesting future experiments, generating reports, and presenting findings to project teams.
Identifying and resolving issues related to reagent performance, assay development, or manufacturing processes.
Working closely with other scientists, engineers, and operations personnel to ensure the successful development and implementation of new reagents.
Adhering to good laboratory practices, maintaining accurate records, and ensuring the proper maintenance of laboratory equipment, laboratory spaces, and inventory.
Keeping up-to-date with scientific literature and technological advancements in the field of reagent development.