Senior Scientist, Assay Development

Flagship Pioneering•Cambridge, MA

About The Position

Flagship Labs 103, Inc. (FL103) is a privately held early-stage company that is building advanced technological and computational platforms to pioneer the detection of cellular dynamics from minimally invasive biospecimens. FL103 was founded by Flagship Pioneering, an innovation enterprise dedicated to originating and developing companies that invent breakthrough technologies that transform health care, agriculture, and sustainability. FL103 is seeking a highly motivated and experienced senior scientist to lead the design, development, optimization and validation of extracellular vesicle based in vitro assays to help diagnose health and disease. The successful candidate will be a driven, experienced scientist who is enthusiastic about developing state-of-the-art techniques to pioneer the detection of low abundance biomarkers from minimally invasive biospecimens in a multiplex format. The position will provide a unique opportunity to play a foundational role in the development of FL103’s innovative bioplatform.

Requirements

PhD in Chemistry, Biochemistry, Molecular Biology or a related discipline with 5+ years of post-graduate experience (industry preferred)
Demonstrated experience developing immunoassays, protein detection methods, molecular diagnostics, etc.
Experience in assay troubleshooting, validation and verification
Clinical sample testing, including plasma and serum
Demonstrated ability to be a thoughtful contributor to experimental design and data analysis
Ability to manage multiple projects, working both independently and collaboratively within a dynamic team
Excellent written and verbal communication skills to present results and scientific data to the internal team and/or collaborators
Enthusiastic about playing a pivotal role in building the foundation of a new biotech company

Nice To Haves

General experience with extracellular vesicles
Experience guiding products from concept through feasibility, validation and launch
Experience working under a quality management system
Demonstrated experience working with established standards related to development and validation of biomarker assays, including CLSI guidelines or working within a CLIA regulated environment

Responsibilities

Optimize and troubleshoot ultrasensitive immunoassay protocols to detect EV markers
Change assay reagents and components to optimize assay performance, driving increases in sensitivity and specificity
Develop laboratory protocols and optimize workflows to build the foundation of FL103’s platform
Maintain scientific and technical expertise through familiarity with scientific literature
Coordinate with Contract Research Organizations (CROs) and external collaborators
Communicate experimental results effectively through oral presentations and written reports, ensuring clear and concise dissemination of information to the FL103 team
Help lead, mentor, and build experimental team