Senior Scientist - Oligo Bioinformatics

Merck•Billerica, MA

12h•Onsite

About The Position

Our Oligonucleotide Therapeutics Group (DDTech) at EMD Serono in Billerica, MA, is expanding, and we are looking for a Senior Scientist in Oligo Bioinformatics to lead the computational design and optimization of our next-generation siRNA and ASO pipelines. In this role, you will sit at the crucial intersection of computational biology, chemistry, and drug discovery—directly shaping therapeutic programs from target identification through lead optimization. If you thrive in a fast-paced, highly collaborative environment where your algorithms directly inform lab experiments, we want to hear from you.

Requirements

PhD in Chemistry, Chemical Engineering or other Science or Engineering discipline
3+ years of dedicated experience within the Oligonucleotide field
Proficient in Bioinformatics tools and software (e.g. BLAST, Ensemb. RNA fold, siRNA design tools)
Experience with common human genetics resources and techniques
Experience with analyzing large genomic and transcriptomic datasets including RNA seq, Single cell RNA seq, splice isoforms and variant database
Highly collaborative and strong problem-solving ability
Strong organizational skills and ability to manage multiple experiments or project priorities in a fast-paced research environment
Excellent written and verbal communication skills and strong scientific curiosity and innovation mindset
Ability to work effectively in a collaborative, cross-functional team environment

Responsibilities

Utilize Bioinformatics platforms to design, evaluate and optimize siRNA and ASO sequences for targeted gene silencing
Analyze gene expression data to identify suitable targets for siRNA/ASO development
Work closely with chemists and biologists to integrate bioinformatics approaches into experimental workflow
Perform transcriptome wide off-target prediction and annotation
Develop pipelines that determine mapping coordinates and homology of oligonucleotides to genomes and transcriptomes
Analyze High through put screening datasets and identify SAR