Senior Scientist (In vitro / Cellular Pharmacology), Cambridge, MA

Isomorphic Labs • Cambridge, MA

4d • Hybrid

About The Position

Isomorphic Labs is seeking exceptional individuals to join a highly impactful In vitro and Cellular Pharmacology sub-team, within our Translational Sciences team. This role is ideal for an experienced in vitro pharmacologist with significant working knowledge of biophysical, biochemical and/or cell-based functional assays, and extensive experience of providing quantitative in-vitro pharmacology expertise within drug discovery projects.
This is an exciting opportunity to work closely with world-leading ML and drug discovery experts to develop imaginative new ways to test biological hypotheses, building a deep mechanistic understanding of drug target interactions to drive our projects forward. You will play a key role in defining the screening cascades for our drug design projects, advancing our oncology, immunology and partnership portfolios from early drug discovery through to candidate selection and ultimately to clinical phase work. By overseeing externalized CRO activities, you will close the loop between computational biological insights and real-world laboratory validation. You will have experience of working broadly across drug discovery projects and have the ability to think originally and critically, knowing when to apply innovative ideas, and think with a fresh approach.

Requirements

• Ph.D. in Pharmacology, Biochemistry, Cell Biology, Biophysics, or a related scientific discipline.
• Extensive experience in the design and implementation of biological screening cascades applied to drug design projects from hit identification to candidate selection phases.
• Deep knowledge of experimental in vitro pharmacology techniques including biophysical, biochemical and/or cellular assays.
• Ability to provide technical guidance within matrixed organizations, effectively steering cross-functional programs and execution through collaboration.
• Experience working with CROs in acquiring and interpreting high quality biological data in a timely manner.
• Dynamism and agility, with ability to work across several projects and therapeutic areas.
• Effective communication across a broad interdisciplinary team, working with key stakeholders with different skills and backgrounds.

Nice To Haves

• Experience of leading biology within drug discovery programs, ideally from inception to clinical candidate delivery.
• Experience partnering with Data Science groups in setting up systems for ingestion of biological data.
• Track record of contributing to drug design projects which have then delivered Clinical Candidates.
• Working knowledge of designing and implementing assays and screening cascades for alternative modalities or alternative chemistries e.g peptides or molecular glues.
• General knowledge of machine learning modelling applied to biological systems and drug discovery.

Responsibilities

• Design efficient and comprehensive biological screening cascades for a variety of internal and partnered drug design programs.
• Guide the optimization and implementation of biophysical and biochemical assays, including SPR, ITC, and enzymatic methodologies, to rigorously evaluate target interaction, pharmacological potency, and molecular specificity.
• Direct the development and refinement of functional and phenotypic cellular assays, bridging the gap between biochemical engagement and biological potency to advance target validation and mechanistic understanding.
• Work with CROs to design decision-making experiments, and deliver the highest quality biological data to inform the path to the clinic.
• Evaluate, interpret, and synthesize complex binding, kinetic, and dose-response information; generate precise technical documentation to guide strategic decision-making and support IND-enabling data packages.
• Act as a vital bridge between computational prediction and experimental reality, collaborating closely with: AI/ML & Data Science teams, Medicinal Chemistry, Structural Biology, In vivo Pharmacology & Translational Sciences.

Benefits

• We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree