Senior Scientist II, Process Chemistry

Revolution Medicines•Redwood City, CA

1d•Hybrid

About The Position

Revolution Medicines is seeking an advanced-career, hands-on process chemistry scientist to lead scientific investigations, coordinate cross-disciplinary decisions, and solve critical problems affecting process transfer and clinical supply. The role owns complex drug substance development work and requires experience supporting regulatory filings, solving problems, and exercising sound technical judgment in complex and ambiguous development situations. The scientist will design and execute pivotal experiments to resolve difficult chemistry problems, develop methods, and test high-impact hypotheses. The role leads investigations into complex reaction behavior, process variability, and impurity formation, and establishes scientifically justified process-control recommendations. It directs integrated process development for assigned programs or complex workstreams, manages a small group of scientists and research associates, and leads technical discussions with analytical development, quality, manufacturing, regulatory, and supply chain partners. The position also directs laboratory scale-up and technology transfer to CDMOs, assesses implementation risks, and leads resolution of significant manufacturing problems. It authors and reviews process chemistry documentation and scientific justifications for regulatory filings, while identifying implications of experimental findings for future development and maintaining laboratory safety and knowledge-capture standards.

Requirements

PhD in organic chemistry and at least 8 years of related experience, which may include postdoctoral research.
Substantial pharmaceutical industry process development experience.
Record of solving complex and ambiguous small-molecule process chemistry problems and delivering robust processes for clinical manufacturing.
Direct experience contributing to regulatory submissions and leading process development, scale-up, and technology transfer activities.
Advanced hands-on synthesis, experimental design, mechanistic reasoning, impurity investigation, and interpretation of analytical evidence.
Demonstrated leadership of cross-disciplinary scientific work and experience supervising scientific staff and developing direct reports.
Strong understanding of cGMP manufacturing, drug substance control strategies, process safety, and development needs from early through later stages.
Ability to make and communicate consequential technical recommendations, balance competing project needs, and remain active in the laboratory.

Nice To Haves

Experience supporting multiple IND submissions or progressing drug substance processes through successive clinical development stages.
Experience developing novel process solutions, leading significant manufacturing investigations, or contributing to scientific publications or intellectual property.

Responsibilities

Design and execute pivotal experiments to resolve difficult chemistry problems, develop methods, and test high-impact scientific hypotheses.
Lead investigations of complex reaction behavior, process variability, and impurity formation, and establish scientifically justified recommendations for process control.
Direct integrated process development across assigned programs or complex workstreams, including technical priorities and evaluation of alternative strategies.
Manage a small group of scientists and research associates through clear objectives, rigorous data review, coaching, and performance feedback.
Lead cross-disciplinary technical discussions and decisions with analytical development, quality, manufacturing, regulatory, and supply chain partners.
Direct laboratory scale-up and technology transfer to CDMOs, evaluate implementation risks, and lead resolution of significant manufacturing problems.
Author and review process chemistry documentation and scientific justifications in support of regulatory filings.
Identify broader implications of experimental findings for subsequent development and influence project strategy.
Maintain strong standards of laboratory safety and knowledge capture.