Scientist II, Process Chemistry

Revolution Medicines•Redwood City, CA

2d•$132,000 - $166,000•Onsite

About The Position

Revolution Medicines is seeking a laboratory-based process chemist to own development workstreams for a small-molecule drug substance. This hands-on individual contributor role involves independently designing and executing experiments, solving complex chemistry problems, and developing robust processes suitable for scale-up and technology transfer. The position carries responsibility for scientific recommendations and delivery of assigned development objectives.

Requirements

PhD in organic chemistry and at least 2 years of related experience, which may include postdoctoral research.
Demonstrated ability to independently design and execute process development studies and solve complex synthetic chemistry problems.
Strong hands-on skills in multistep synthesis, reaction optimization, isolation, and characterization using NMR, chromatography, and mass spectrometry.
Ability to connect experimental results with process robustness, scale-up considerations, and project objectives.
Experience taking responsibility for a defined scientific workstream and providing technical guidance to colleagues.
Clear scientific writing and effective collaboration.
Proficiency with electronic laboratory notebooks, data analysis tools, and ChemDraw.

Nice To Haves

Industry experience in pharmaceutical process development, laboratory scale-up, crystallization, or technology transfer to CDMOs.
Experience with design of experiments, automated laboratory reactors, cGMP manufacturing, or drug substance regulatory documentation.

Responsibilities

Own development of reactions, process steps, or development workstreams; set experimental approaches and coordinate work to meet project objectives.
Design and execute experiments to evaluate alternative routes and optimize reactions, workup, isolation, and crystallization conditions.
Investigate reaction behavior and impurity formation using mechanistic reasoning, experimental design, analytical data, and scientific literature.
Develop robust processes by defining parameter sensitivity, reproducibility, impurity control, solubility limits, and other manufacturing requirements.
Plan and execute laboratory studies and translate results into recommendations for large-scale process implementation.
Prepare technology transfer procedures and work with external CDMOs to resolve implementation issues.
Author process development reports and technical content supporting regulatory documentation, and maintain complete electronic laboratory records.
Provide scientific guidance to research associates, present recommendations to project teams, and identify and address laboratory and process safety risks.