Senior Scientist II, Computational Biology

Eikon Therapeutics•Millbrae, CA

About The Position

Eikon Therapeutics seeks a Senior Scientist in Computational Biology to advance early drug discovery efforts across its target portfolio. The role uses rigorous analytical skills in close collaboration with discovery scientists to conceive and evaluate complex experiments that enable program progress. The scientist will help shape how Eikon evaluates and adopts novel experimental systems and partner with colleagues developing quantitative models to ensure new computational methods are grounded in sound biological reasoning. The successful candidate will bring deep technical and biological knowledge, methodological creativity, and experience with traditional and emerging drug discovery technologies. They will synthesize data from diverse internal and external sources to address nuanced scientific questions and work effectively in a fast-paced, cross-functional environment. Eikon Therapeutics is a biopharmaceutical company combining chemistry, engineering, computation, and biology. Its discovery platform uses microscopes that enable real-time, molecular-resolution measurements of protein movement in living cells to identify otherwise intractable classes of proteins as drug targets.

Requirements

Postdoctoral fellowship plus 4 years of relevant experience, or a PhD in bioinformatics, computational biology, or a quantitative field with deep expertise in statistics or method development plus 7 years of relevant industry experience.
Hands-on experience developing and applying methods for high-dimensional, multimodal datasets, including designing, evaluating, and integrating high-throughput experiments.
Ability to independently define analytical approaches for novel technologies, develop effective solutions, and validate results with minimal oversight.
Proven experience analyzing complex genomics datasets across one or more modalities, such as bulk, single-cell, or spatial transcriptomics; pooled or arrayed CRISPR screens; MAVEs or other multiplexed reporter assays; high-content imaging data; Perturb-seq; or other relevant technologies.
Experience working with large consortia and public datasets such as UK Biobank, TCGA, GTEx, ENCODE, gnomAD, and Human Cell Atlas.
Expertise using one or more high-level programming languages, such as R or Python, to solve biological problems; familiarity with modern coding and computing best practices such as cloud deployment, version control, and containerization.
Demonstrated record of impactful research, evidenced by peer-reviewed publications.
Excellent interpersonal, written, and verbal communication skills.

Nice To Haves

Experience partnering with computational or algorithms teams on statistical or machine-learning model development and/or methodological development.

Responsibilities

Drive the development and adoption of novel experimental systems and techniques relevant to Eikon’s target portfolio, collaborating with experimental and computational teams across programs.
Develop and apply analytical approaches, statistical methods, and proof-of-concept tools to support new experimental strategies.
Analyze multimodal data to evaluate experimental systems, identify enabling insights, and define the limits of interpretation for biological applications.
Apply statistical, biological, and experimental expertise to evaluate complex experiments.
Distill information from diverse sources to reach relevant and testable biological conclusions.

Benefits

Bonus and equity compensation.
401(k) plan with company matching.
Medical insurance premiums covered by Eikon at 95%.
Dental and vision insurance premiums covered by Eikon at 100%.
Mental health and wellness benefits.
Weeklong summer and winter holiday shutdowns.
Generous paid time off and holiday policies.
Life/AD&D insurance premiums covered by Eikon at 100%, with optional supplemental employee-paid life/AD&D policies.
Enhanced parental leave benefit.
Daily subsidized lunch program when on-site.