Senior Scientist II, Computational Biology
About The Position
Eikon Therapeutics is seeking a Senior Scientist in Computational Biology to advance early drug discovery efforts across its target portfolio. The role involves collaborating closely with discovery scientists to conceive and evaluate complex experiments, helping shape the evaluation and adoption of novel experimental systems, and partnering with quantitative modeling colleagues to ensure computational methods are grounded in sound biological reasoning. The successful applicant will bring rigorous analytical skills, scientific depth, methodological creativity, and strong biological knowledge to synthesize data from diverse sources and resolve nuanced scientific questions in a fast-paced, cross-functional environment.
Requirements
- Postdoctoral fellowship plus 4 years of relevant experience, or a PhD in bioinformatics, computational biology, or a quantitative field with deep expertise in statistics or method development, plus 7 years of relevant industry experience.
- Hands-on experience developing and applying methods for high-dimensional, multimodal datasets, including designing, evaluating, and integrating high-throughput experiments.
- Ability to independently define analytical approaches for novel technologies, develop effective solutions, and validate results with minimal oversight.
- Proven experience analyzing complex genomics datasets across one or more technical modalities, such as bulk, single-cell, or spatial transcriptomics; pooled or arrayed CRISPR screens; MAVEs or other multiplexed reporter assays; high-content imaging data; Perturb-seq; or other relevant technologies.
- Experience working with large consortia and public datasets such as UK Biobank, TCGA, GTEx, ENCODE, gnomAD, and Human Cell Atlas.
- Expertise in one or more high-level programming languages, such as R or Python, to solve biological problems.
- Familiarity with modern coding and computing best practices, such as cloud deployment, version control, and containerization.
- Demonstrated record of impactful research, evidenced by publications in peer-reviewed journals.
- Excellent interpersonal, written, and verbal communication skills.
Nice To Haves
- Experience partnering with computational or algorithms teams on statistical or machine-learning model development and/or methodological development.
Responsibilities
- Drive the development and adoption of novel experimental systems and techniques relevant to Eikon’s target portfolio, collaborating with experimental and computational teams across programs.
- Develop and apply analytical approaches, statistical methods, and proof-of-concept tools to support new experimental strategies.
- Analyze multimodal data to evaluate experimental systems, identify enabling insights, and define the limits of interpretation for biological applications.
- Apply statistical, biological, and experimental expertise to evaluate complex experiments, distill information from diverse sources, and reach relevant, testable biological conclusions.
Benefits
- 401(k) plan with company matching.
- Medical insurance, with premiums covered by Eikon at 95%.
- Dental and vision insurance, with premiums covered by Eikon at 100%.
- Mental health and wellness benefits.
- Weeklong summer and winter holiday shutdowns.
- Generous paid time off and holiday policies.
- Life and AD&D insurance, with premiums covered by Eikon at 100%, and optional supplemental employee-paid life and AD&D policies.
- Enhanced parental leave benefit.
- Daily subsidized lunch program when on-site.
- Bonus and equity compensation.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
