Senior Scientist II, Biomolecular Characterization

BigHat Biosciences•San Mateo, CA

1d•$145,000 - $165,000•Onsite

About The Position

BigHat Biosciences is seeking an exceptional individual for a Senior Scientist I/II, Biomolecular Characterization role to drive characterization of in vitro antibody-target binding behavior. At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more or less experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.

Requirements

M.Sc/Ph.D. in molecular or cell biology, immunology, or related fields.
5+ years of advanced, independent research experience in an industry setting, including substantial experience with the Octet BLI and/or Biacore platforms.
Practical and theoretical fluency with using various BLI sensor types for the determination of antibody-antigen binding kinetics and epitope binning.
Deep technical knowledge regarding chip chemistries and characteristics for SPR measurements.
Experience measuring binding interactions with recombinant soluble, transmembrane, and cell based antigens and a variety of antibody formats.
Ability to manage and prioritize requests from cross-functional stakeholders.
Strong data analysis and interpretation skills.
Exceptional written, verbal, and visual communication skills.
Ability to educate and build consensus among diverse stakeholders regarding scientific direction.

Nice To Haves

Experience managing teams or demonstrated mentorship of junior scientists strongly preferred.
Experience with lab automation is a plus.

Responsibilities

Individual contribution at the bench with strong cross-functional collaboration with scientists, ML/DS, and program teams.
Develop, optimize, and implement high- and low-throughput state-of-the-art strategies to characterize the interactions between antibody and antigen using biolayer interferometry (BLI) and surface plasmon resonance (SPR).
Design and perform epitope binning assays to cluster antibodies into functional families.
Source, develop, and validate competitive binding/blocking assays to triage candidate antibodies.
Collaborate closely with the BigHat science organization to accelerate hits from discovery through lead optimization and candidate nomination.
Effectively synthesize and communicate results and research activity to key decision-makers and the broader BigHat team, as well as to external partners.