Senior Scientist I, Biotherapeutic Production Technologies

Generate Biomedicines•Andover, MA

6d•$125,000 - $175,000

About The Position

Generate:Biomedicines is seeking an experienced Senior Scientist I to independently lead complex protein production and characterization efforts in support of drug discovery and platform initiatives. This individual-contributor role spans construct and expression strategy, mammalian and cell-free protein production, downstream purification, and fit-for-purpose analytical characterization. The role defines technical approaches, integrates data across workflows, and makes recommendations that support scientific decisions across protein modalities and stages of work. The Senior Scientist I serves as a technical point of contact for protein purification and characterization strategy, partnering with cross-functional teams and external collaborators to align material quality, scale, timelines, and downstream requirements. The role also advances scalable, data-rich workflows to improve throughput, reproducibility, and organizational learning. The position combines hands-on science with technical ownership and broad collaboration. It contributes to the quality, speed, scale, and reproducibility of workflows used across discovery and platform initiatives, supporting the advancement of next-generation biologics.

Requirements

Ph.D. in biochemistry, molecular biology, bioengineering, chemical engineering, protein sciences, or a related discipline, with typically 4 or more years of relevant industry experience; or a B.S. or M.S. in a relevant scientific or engineering discipline, with typically 12 or more years of relevant industry experience; or an equivalent combination of education and experience demonstrating the required technical depth, independent judgment, and scope of impact.
Ability to independently define, plan, and execute complex protein production, purification, and characterization strategies across multiple discovery and platform initiatives.
Experience leading protein expression workflow design, optimization, scale-up, and troubleshooting, including transient mammalian and cell-free protein synthesis platforms.
Experience leading purification workflow development from capture through polishing, designing and interpreting chromatography screening studies, and translating processes across scales.
Ability to produce protein material across formats and scales and establish fit-for-purpose quality attributes and acceptance criteria with downstream stakeholders.
Ability to select, apply, and interpret analytical and biochemical methods for protein characterization.
Ability to integrate data, identify root causes, resolve complex technical challenges, evaluate trade-offs, and communicate scientific recommendations and uncertainty clearly.
Ability to serve as a technical point of contact and influence cross-functional decisions.
Ability to lead technical interactions with external partners, including defining work packages, supporting transfers, reviewing data, troubleshooting, and assessing deliverables.
Ability to develop scalable, reproducible, and well-documented workflows and contribute to scientific quality and delivery.

Nice To Haves

Experience with stable-expression systems and stable cell-line development activities.
Experience with construct design, cloning, vector design, or related molecular-biology workflows.
Experience working with engineered proteins, multispecifics, novel scaffolds, or other complex protein modalities.
Experience integrating protein design information into expression, purification, or characterization strategies.
Experience with automation, high-throughput experimentation, laboratory information systems, or structured experimental-data environments.
Experience managing technical work conducted by CRO, CDMO, or vendor partners.
Experience developing workflows or methods adopted beyond an immediate project or work group.

Responsibilities

Independently define, plan, and execute complex protein production, purification, and characterization strategies across discovery and platform initiatives; establish technical milestones, decision criteria, dependencies, and risk-mitigation plans.
Lead the design, optimization, scale-up, and troubleshooting of protein expression workflows, including transient mammalian and cell-free protein synthesis platforms; provide technical input on construct design, molecular biology, and stable-expression activities as needed.
Lead purification workflow development from capture through polishing, particularly for larger-scale or later-stage protein production; design and interpret chromatography screening studies, including predictor-plate approaches, resin selection, operating-condition optimization, and scale translation.
Produce high-quality protein material across a range of formats and scales, and partner with downstream stakeholders to establish fit-for-purpose quality attributes and acceptance criteria based on intended use.
Select, apply, and interpret analytical and biochemical characterization methods to assess protein purity, identity, concentration, oligomeric state, aggregation, stability, and other relevant quality attributes.
Integrate expression, purification, and characterization data to identify root causes, resolve technical challenges, evaluate trade-offs, and recommend next steps; communicate the evidence, assumptions, risks, and uncertainty supporting technical decisions.
Serve as a technical point of contact for protein production, purification, and characterization strategy, translating scientific findings into recommendations for discovery, platform, analytical, and data-focused partners.
Lead technical interactions with CROs, CDMOs, vendors, and other external partners, including defining technical work packages, supporting method or process transfer, reviewing data, troubleshooting issues, and ensuring deliverables meet scientific requirements.
Drive development of scalable, reproducible, well-documented workflows and advance the use of automation, high-throughput approaches, structured experimental data, and AI/ML-enabled tools to improve scientific productivity and learning.
Develop and share new methods, technical standards, and best practices; advise and mentor colleagues, provide scientific feedback, and contribute to an inclusive, collaborative team.
Track progress, proactively surface risks, and communicate successes, setbacks, and lessons learned with clarity and transparency.