Scientist I, Biologics Production
About The Position
PharmaEssentia Innovation Research Center (PIRC) is seeking a motivated and collaborative Scientist I, Biologics Production to join its Biologics Platform Team. The role supports discovery and early development of innovative therapeutics, including monoclonal antibodies, multispecifics, cytokines, and other protein therapeutics, by establishing, optimizing, and scaling workflows for recombinant protein and antigen production and characterization. The position focuses on medium- to high-throughput mammalian cell culture using CHO and HEK expression systems, transient protein expression, purification, and analytical characterization. The Scientist will help establish and operate discovery-stage workflows for mammalian expression, purification, and fit-for-purpose characterization of recombinant proteins and antigens, while improving throughput, turnaround time, reproducibility, and capacity. The role also contributes to scalable production platforms that support multiple discovery programs.
Requirements
- Ph.D. in Biochemistry, Biophysics, Chemical Engineering, Cell Biology, Molecular Biology, or a related scientific discipline, with 0–2 years of relevant industry or academic experience; or an MS in a related discipline with 6+ years of industry experience.
- Experience producing antibodies, antigens, multispecifics, or other protein-based therapeutics.
- Demonstrated experience performing 24- to 96-well recombinant-protein expression and purification workflows in mammalian systems.
- Experience with protein purification using FPLC/ÄKTA systems, including development and troubleshooting of chromatography-based purification methods.
- Experience with fit-for-purpose characterization of recombinant proteins using techniques such as SDS-PAGE, SEC, BLI, and/or SPR.
- Ability to independently advance experimental work, troubleshoot technical challenges, and communicate scientific findings clearly.
- Strong organizational, documentation, and data-analysis skills, with the ability to manage multiple protein-production activities in a dynamic research environment.
- Collaborative, flexible, and team-oriented mindset, with the ability to work effectively across internal and external research partners.
Nice To Haves
- Familiarity with laboratory automation, data-management systems, or workflow-standardization approaches, such as Hamilton or Tecan systems.
- Experience with wave-bag or Ambr expression systems.
- Experience with molecular cloning and construct design supporting protein expression.
- Hands-on experience with intact-mass and LC-MS characterization of antibodies and other protein-based therapeutics.
- Working knowledge of protein developability, biophysical characterization, and early biologics discovery workflows.
- Experience supporting technology transfer, external CRO activities, or cross-functional discovery programs.
Responsibilities
- Execute medium- to high-throughput mammalian cell culture and recombinant protein expression workflows, including transient expression approaches.
- Develop methods and techniques to improve throughput, reproducibility, turnaround time, and production capacity in support of biologics discovery programs.
- Purify recombinant proteins using FPLC/ÄKTA-based chromatography workflows.
- Perform fit-for-purpose protein quality and characterization assessments to guide production, purification, and downstream study decisions.
- Troubleshoot expression, purification, yield, purity, stability, quality, and throughput challenges; identify and implement practical solutions.
- Collaborate with internal research teams, CROs, and external partners to coordinate protein-production activities, communicate technical requirements, and integrate results into project decisions.
- Maintain clear experimental documentation and prepare scientific reports, presentations, and data summaries.
- Contribute scientific input within project teams and stay current with emerging technologies in protein expression, purification, and biologics platform development.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
