Senior Scientist I, Biotherapeutic Production Technologies

Generate Biomedicines•Andover, MA

18h•Onsite

About The Position

Generate:Biomedicines is seeking an experienced Senior Scientist I to independently lead complex protein production and characterization efforts supporting drug discovery and platform initiatives. This individual-contributor role spans upstream construct and expression strategy, mammalian and cell-free protein production, downstream purification, and fit-for-purpose analytical characterization. The Senior Scientist defines technical approaches, integrates data across workflows, and makes recommendations that support scientific decisions across protein modalities and stages of work. The role serves as a technical point of contact for protein purification and characterization strategy, partnering with cross-functional teams and external collaborators to align material quality, scale, timelines, and downstream requirements. It also advances scalable, data-rich workflows to improve throughput, reproducibility, and organizational learning. The position combines hands-on science and technical ownership with broad collaboration and the opportunity to develop approaches that enable next-generation biologics. Generate:Biomedicines is a clinical-stage generative biology company that integrates machine learning with large-scale experimentation to design proteins with defined biological intent. Founded in 2018, the company is advancing clinical and preclinical programs across multiple disease areas and protein modalities.

Requirements

Ph.D. in biochemistry, molecular biology, bioengineering, chemical engineering, protein sciences, or a related discipline, with typically 4 or more years of relevant industry experience; or
B.S. or M.S. in a relevant scientific or engineering discipline, with typically 12 or more years of relevant industry experience; or
An equivalent combination of education and experience demonstrating the technical depth, independent judgment, and scope of impact required for the role.
Ability to independently define, plan, and execute complex protein production, purification, and characterization strategies across discovery and platform initiatives.
Experience or capability leading design, optimization, scale-up, and troubleshooting of transient mammalian and cell-free protein expression workflows.
Ability to lead purification workflow development from capture through polishing and design and interpret chromatography screening and scale-translation studies.
Ability to select, apply, and interpret analytical and biochemical methods for protein characterization.
Ability to integrate workflow data, resolve complex technical challenges, evaluate trade-offs, and communicate technical recommendations, evidence, risks, and uncertainty.
Ability to collaborate across functions and manage technical interactions with external partners.
Ability to develop scalable, reproducible, and well-documented workflows and contribute to scientific quality and delivery.

Nice To Haves

Experience with stable-expression systems and stable cell-line development activities.
Experience with construct design, cloning, vector design, or related molecular-biology workflows.
Experience working with engineered proteins, multispecifics, novel scaffolds, or other complex protein modalities.
Experience integrating protein design information into expression, purification, or characterization strategies.
Experience with automation, high-throughput experimentation, laboratory information systems, or structured experimental-data environments.
Experience managing technical work conducted by CRO, CDMO, or vendor partners.
Experience developing workflows or methods adopted beyond an immediate project or work group.

Responsibilities

Independently define, plan, and execute complex protein production, purification, and characterization strategies across discovery and platform initiatives.
Establish technical milestones, decision criteria, dependencies, and risk-mitigation plans.
Lead the design, optimization, scale-up, and troubleshooting of protein expression workflows, including transient mammalian and cell-free protein synthesis platforms.
Provide technical input into construct design, molecular biology, and stable-expression activities as needed.
Lead purification workflow development from capture through polishing, with emphasis on larger-scale or later-stage protein production.
Design and interpret chromatography screening studies, including predictor-plate approaches, resin selection, operating-condition optimization, and scale translation.
Produce high-quality protein material across a range of formats and scales.
Partner with downstream stakeholders to establish fit-for-purpose quality attributes and acceptance criteria based on intended use.
Select, apply, and interpret analytical and biochemical characterization methods to assess protein purity, identity, concentration, oligomeric state, aggregation, stability, and other relevant quality attributes.
Integrate expression, purification, and characterization data to identify root causes, resolve technical challenges, evaluate trade-offs, and recommend next steps.
Communicate the evidence, assumptions, risks, and uncertainty supporting technical decisions.
Serve as a technical point of contact for protein production, purification, and characterization strategy.
Influence cross-functional decisions by translating scientific findings into recommendations for discovery, platform, analytical, and data-focused partners.
Lead technical interactions with CROs, CDMOs, vendors, and other external partners, including defining technical work packages, supporting method or process transfer, reviewing data, troubleshooting, and ensuring deliverables meet scientific requirements.
Drive development of scalable, reproducible, and well-documented workflows.
Advance the use of automation, high-throughput approaches, structured experimental data, and AI/ML-enabled tools to improve scientific productivity and learning.
Develop and share new methods, technical standards, and best practices.
Advise and mentor colleagues, provide constructive scientific feedback, and contribute to an inclusive, collaborative, high-performing team.
Track progress, proactively surface risks, and communicate successes, setbacks, and lessons learned clearly and transparently.