Senior Scientist, Cell Therapy Genetic Regulation
About The Position
Johnson & Johnson is seeking a motivated, high-performing Senior Scientist to join the Cell and Genetic Medicines group within Therapeutics Discovery and support the development of CAR T cell therapy programs. The role applies genetic regulation approaches to develop and implement gene modulation strategies that enhance the safety, efficacy, persistence, and functionality of CAR T cell therapy platforms. The scientist will work directly with human T cells, including culture, activation, expansion, and genetic modification. They will design, optimize, and deploy genetic regulation tools and screening workflows to support discovery and advancement of next-generation cell therapy programs. The position requires technical expertise in genetic engineering, independent laboratory work, and collaboration across cross-functional teams.
Requirements
- PhD in Molecular Biology, Bioengineering, Genetics, or a related biological research discipline.
- Minimum 2 years of post-PhD experience; biopharmaceutical or biotech experience is preferred.
- Strong knowledge of genetic regulation strategies and genetic modulation technologies.
- Demonstrated experience designing, screening, and validating genetic regulation tools in a cell therapy-relevant context.
- Ability to independently perform laboratory responsibilities with limited guidance.
- Strong collaborative skills and experience coordinating experiments and data exchange across teams.
- Self-motivated, highly organized, and able to manage competing priorities in a fast-paced discovery environment.
Nice To Haves
- Hands-on experience in molecular cloning, including designing, constructing, and screening pooled libraries for high-throughput assays.
- Experience with primary human T cell culture, expansion, and genetic engineering, including viral transduction and/or non-viral gene editing.
- Experience in lentiviral vector design and optimization.
- Familiarity with flow cytometry, next-generation sequencing, and basic bioinformatics analyses.
Responsibilities
- Lead development of genetic regulation tools tailored for multiple cell therapy platforms.
- Design, execute, and optimize screening workflows to identify and validate gene modulation designs.
- Advance assay development and validation pipelines to ensure on-target activity, specificity, and functional effects in relevant cell therapy platforms.
- Collaborate with team members and cross-functional teams to drive project milestones, produce shared data packages, and align experimental plans with program timelines.
- Stay current on scientific and technological advancements in genetic regulation and cell therapy, incorporate new knowledge into projects, and propose research directions.
- Analyze experimental data, prepare technical reports, and communicate results to senior leadership, internal partners, and external partners as required.
- Maintain accurate experimental procedures, data, and results in an electronic laboratory notebook and comply with laboratory protocols and safety procedures.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
