Scientist 3, Cell Therapy T cell Differentiation
About The Position
The Cell Therapy department within Genentech Research and Early Development (gRED) is seeking a motivated, collaborative Scientist 3 to advance next-generation, off-the-shelf cell therapies for patients with intractable diseases. Reporting to a Principal Fellow, the Scientist will help shape the iPSC-to-T cell differentiation platform and influence pipeline programs and mechanistic biology discoveries. This lab-based role is located at Genentech’s South San Francisco, California campus and requires onsite presence. Relocation benefits are available. The expected salary range for the position, based on the primary location of California, is $103,400–$192,000. Actual pay depends on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance. The position also qualifies for benefits detailed through the company’s benefits link.
Requirements
- PhD in Immunology, Stem Cell Biology, Cell & Molecular Biology, or a related field.
- At least 3 years of relevant experience.
- Extensive hands-on experience differentiating iPSCs to T cells and/or other immune cell lineages.
- Strong cell and molecular biology background and ability to use mechanistic approaches to investigate cell fate decisions.
- Track record of evaluating and optimizing the robustness, consistency, and reproducibility of stem cell differentiation platforms.
- Deep experience developing and applying phenotypic and functional assays to characterize T-cell activity, fitness, and potency.
- Strong organizational, written, and verbal communication skills.
- Demonstrated history of collaborative delivery across multidisciplinary teams.
Nice To Haves
- Experience with Design of Experiments (DOE), high-throughput screening, or other quantitative multivariate process-optimization methodologies.
- Prior experience in cell therapy or drug development and understanding of critical quality attributes, including identity, purity, yield, viability, and potency.
- Hands-on expertise with CRISPR/Cas9 or other genome-engineering modalities in iPSCs.
- Scientific impact demonstrated through high-impact publications, patents, or contributions to therapeutic advancement.
Responsibilities
- Develop, optimize, and implement robust iPSC-to-T cell differentiation protocols for diverse therapeutic programs.
- Investigate cellular and molecular mechanisms underlying T-cell lineage specification, differentiation efficiency, and maturation to improve processes.
- Translate biological discoveries into improvements in cell-product quality, yield, phenotype, and function.
- Analyze complex, multidimensional datasets and use findings to guide subsequent experimental strategies.
- Collaborate with research, translational, computational, process development, and external partner groups across gRED.
- Contribute to scientific and strategic planning for the Cell Therapy department and Genentech’s broader therapeutic pipeline.
Benefits
- Relocation benefits are available.
- A discretionary annual bonus may be available based on individual and company performance.
- The position qualifies for the benefits detailed at the company’s benefits link.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
