Scientist 3, Cell Therapy T cell Differentiation

Roche • South San Francisco, CA

4d • $103,400 - $192,000 • Onsite

About The Position

The Cell Therapy department within Genentech Research and Early Development (gRED) is seeking a motivated, collaborative Scientist 3 to advance next-generation, off-the-shelf cell therapies for patients with intractable diseases. Reporting to a Principal Fellow, the Scientist will help shape the iPSC-to-T cell differentiation platform and influence pipeline programs and mechanistic biology discoveries. This is a lab-based role at Genentech’s South San Francisco, California campus, and onsite presence is required.

Requirements

• PhD in Immunology, Stem Cell Biology, Cell & Molecular Biology, or a related field.
• At least 3 years of relevant experience.
• Extensive hands-on experience differentiating iPSCs to T cells and/or other immune cell lineages.
• Strong cell and molecular biology background and demonstrated ability to use mechanistic approaches to investigate cell fate decisions.
• Proven track record evaluating and optimizing the robustness, consistency, and reproducibility of stem cell differentiation platforms.
• Deep experience developing and applying phenotypic and functional assays to characterize T-cell activity, fitness, and potency.
• Strong organizational, written, and verbal communication skills.
• Demonstrated history of collaborative delivery across multidisciplinary teams.

Nice To Haves

• Experience with Design of Experiments (DOE), high-throughput screening, or other quantitative multivariate process-optimization methodologies.
• Prior experience in cell therapy or drug development and understanding of critical quality attributes, including identity, purity, yield, viability, and potency.
• Hands-on expertise with CRISPR/Cas9 or other genome-engineering modalities in iPSCs.
• Demonstrated scientific impact through high-impact publications, patents, or contributions to therapeutic advancement.

Responsibilities

• Develop, optimize, and implement robust iPSC-to-T cell differentiation protocols for diverse therapeutic programs.
• Investigate cellular and molecular mechanisms underlying T-cell lineage specification, differentiation efficiency, and maturation to drive process enhancements.
• Translate biological discoveries into improvements in cell-product quality, yield, phenotype, and function.
• Analyze complex, multidimensional datasets to draw conclusions and guide subsequent experimental strategies.
• Collaborate with research, translational, computational, process development, and external partner groups across gRED.
• Contribute to scientific and strategic planning for the Cell Therapy department and Genentech’s broader therapeutic pipeline.

Benefits

• Relocation benefits are available.
• A discretionary annual bonus may be available based on individual and Company performance.
• The position qualifies for company benefits; details are available via a link in the posting.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree