Senior Scientist, Antibody Engineering - Oligonucleotide Delivery

Regeneron Pharmaceuticals • Tarrytown, GA

5d • Onsite

About The Position

We are seeking a skilled and motivated Senior Scientist to join our research team focused on innovative oligonucleotide therapeutics strategies. The Senior Scientist will lead projects to develop novel oligonucleotide delivery methods and optimize approaches for oligonucleotide therapeutics quantification across diverse biological matrices; will collaborate across multidisciplinary teams and participate in strategic planning. Responsibilities include mentoring junior scientists, managing laboratory resources, and preparing scientific reports and presentations. The ideal candidate will have a solid base in molecular biology, nucleic acid technologies, and antibody engineering, with a consistent track record to drive innovation in oligonucleotide-related fields. This role offers the chance to create impactful discoveries in oligonucleotide-based therapeutics.

Requirements

• A PhD in Molecular biology, biochemistry, or related field.
• Research experience in genetics medicine.
• Validated experience and strong proficiency in molecular biology methods, including PCR, qPCR, cloning, and nucleic acid purification; as well as experience in troubleshooting and optimizing protocols.
• Consistent record of strong analytical and quantitative skills, with expertise in quantitative assays (e.g., ELISA, digital PCR, fluorescence-based detection) for analyzing oligonucleotides and proteins in biological samples.
• Validated ability to lead research projects, mentor junior scientists, and work effectively within multidisciplinary teams.
• Skilled in preparing scientific reports, presentations, and publications, with strong written and verbal communication abilities.
• A creative problem solver with a track record of proposing and implementing novel solutions in oligonucleotide therapeutics and related fields.
• Hands-on experience with mammalian cell culture and working with preclinical animal models for evaluating oligonucleotide delivery and efficacy.

Nice To Haves

• Good understanding in RNAi technologies, experience with optimizing delivery of RNAi molecules to target cells, evaluating knockdown efficiency; familiarity with in vitro and in vivo models to study RNAi-mediated gene regulation, quantitative assays to measure gene expression changes.
• Experience/skills in protein engineering, particularly in designing and modifying antibodies for improved specificity and affinity.
• Experience with antibody-drug conjugates (ADCs), bispecific antibodies, and other formats used for targeted delivery of therapeutics.
• Understanding of strategies to link antibodies to oligonucleotides or nanoparticles for enhanced cellular uptake and tissue targeting.

Responsibilities

• Developing and applying in vitro and in vivo strategies to improve oligonucleotide delivery efficiency; evaluating and optimizing delivery modalities (e.g., conjugates, nanoparticles); assessing uptake and target gene knockdown in relevant cellular and animal models; troubleshooting delivery barriers; and integrating pharmacokinetic and bio-distribution data with chemistry and in vivo teams to refine approaches.
• Designing and implementing in vitro and in vivo oligonucleotide tracing for advanced detection and analysis; collaborating on labeling techniques (e.g., fluorescent, radioactive, enzymatic tags); establishing sensitive detection protocols; analyzing tissue and cellular distribution; applying quantitative assays to monitor oligonucleotide fate and function; and interpreting complex data to inform therapeutic development.
• Exploring new directions in oligonucleotide technology development, including novel chemical modifications, targeting strategies, and combination therapies; staying current with advancements; proposing innovative project ideas; conducting proof-of-concept experiments; and collaborating with cross-functional teams to translate findings into next generation platforms.
• Mentoring junior scientists.
• Managing laboratory resources.
• Preparing scientific reports and presentations.

Benefits

• health and wellness programs (including medical, dental, vision, life, and disability insurance)
• fitness centers
• 401(k) company match
• family support benefits
• equity awards
• annual bonuses
• paid time off
• paid leaves (e.g., military and parental leave)

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree