Senior Research Scientist I; Process Development Science

Curia • Hopkinton, MA

6d • $113,700 - $145,800 • Onsite

About The Position

Curia is seeking a Senior Research Scientist I, Process Development Science, to steer development programs for protein-based technologies. The role develops purification schemes for a wide range of protein-based technologies, including antibodies and bispecifics, and contributes to expanding the downstream process capabilities of the team. The successful candidate will handle multiple projects, prioritize work to meet timelines, and thrive in a fast-paced environment.

The position involves investigating analytical results, reviewing scientific literature, designing and optimizing purification methods, documenting work, and supporting cGMP production and technology transfer. It also includes maintaining laboratory instruments and mentoring and supervising staff. Work is performed in office and laboratory environments, with possible exposure to biological and chemical hazards.

Requirements

• Bachelor's degree in Biology, Biochemistry, Chemical Engineering, or a related field and 9–13 years of direct hands-on experience with protein purification techniques; or a master's degree in one of these fields and 7–11 years of experience; or a Ph.D. in one of these fields and 4–8 years of experience.
• Hands-on experience with protein purification techniques such as chromatography and tangential flow filtration.
• Proficiency in protein purification using affinity, ion exchange, and hydrophobic interaction chromatography with FPLC systems.
• Ability to apply scientific principles and personal experience to design and execute experiments that solve problems.
• Ability to prioritize responsibilities, multitask, and remain flexible as needs change.
• Motivation and ability to work under tight deadlines.
• Strong interpersonal, oral, and written communication skills.
• Good documentation and organizational skills.
• Ability to work effectively in cross-functional teams to solve process development problems or implement improved procedures.
• Must pass a background check and drug screen; may be required to pass Occupational Health Screening.

Nice To Haves

• Working knowledge of experimental design and data analysis using Design of Experiments (DOE).

Responsibilities

• Develop protein purification schemes for a wide class of protein-based technologies, including antibodies and bispecifics.
• Independently investigate complex analytical results and provide robust solutions.
• Review literature to generate purification scheme proposals.
• Analyze, interpret, and clearly present results in summaries.
• Generate and follow SOPs for cGMP production of material.
• Maintain laboratory instruments.
• Document results in laboratory notebooks and batch records.
• Follow SOPs for mammalian cell culture and protein and antibody purification.
• Optimize methods and facilitate technology transfer to contract manufacturing organizations.
• Troubleshoot process development issues using critical and creative thinking.
• Work independently and collaboratively to complete projects.
• Mentor and supervise staff and work effectively with management teams.

Benefits

• Generous benefit options, eligible from the first day of employment.
• Paid training, vacation, and holidays; vacation accrual begins on the first day of employment.
• Career advancement opportunities.
• Education reimbursement.
• 401(k) program.
• Learning platform.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior