Senior Research Scientist I; Process Development Science

Curia

5d • Onsite

About The Position

Curia is seeking a Senior Research Scientist I for Process Development Science in Hopkinton, Massachusetts. The role steers development programs for protein-based technologies and contributes to expanding the team’s downstream process capabilities. The scientist develops purification schemes for a wide range of technologies, including antibodies and biospecifics, and is expected to manage multiple projects, prioritize tasks, and work effectively in a fast-paced environment.

The position combines independent scientific investigation and problem-solving with collaborative project work. The scientist analyzes and presents results, creates and follows procedures and documentation for cGMP material production, maintains laboratory instruments, and optimizes methods for transfer to contract manufacturing organizations. The role may include supervisory responsibilities, including mentoring and supervising staff.

Work is performed in an office and laboratory environment, with possible exposure to biological and chemical hazards. The employee may need to wear personal protective equipment. The physical requirements include frequently standing, walking, sitting, using and reaching with hands and arms, and lifting or carrying objects up to 30 pounds.

Requirements

• Bachelor’s degree in Biology, Biochemistry, Chemical Engineering, or a related field and 9–13 years of direct hands-on experience with protein purification techniques such as chromatography and tangential flow filtration; OR a master’s degree in one of these fields and 7–11 years of such experience; OR a Ph.D. in one of these fields and 4–8 years of such experience.
• Proficiency in protein purification using affinity, ion exchange, and hydrophobic interaction chromatography with FPLC systems.
• Ability to apply scientific principles and personal experience to design and execute experiments to solve problems.
• Ability to prioritize responsibilities, multitask, and remain flexible as needs change.
• Motivation and ability to work under tight deadlines.
• Strong interpersonal, oral, and written communication skills.
• Good documentation and organizational skills.
• Ability to work effectively in cross-functional teams to solve process development problems or implement improved procedures.
• Must pass a background check and drug screen.
• May be required to pass Occupational Health Screening.

Nice To Haves

• Working knowledge of experimental design and data analysis using Design of Experiments (DOE).

Responsibilities

• Develop protein purification schemes for a wide class of protein-based technologies, including antibodies and biospecifics.
• Independently investigate complex analytical results and provide robust solutions.
• Review literature to generate purification scheme proposals.
• Analyze, interpret, and clearly present results in summaries.
• Generate and follow SOPs for cGMP production of material.
• Maintain laboratory instruments.
• Document results in laboratory notebooks and batch records.
• Follow SOPs for mammalian cell culture and protein or antibody purification.
• Optimize methods and facilitate technology transfer to contract manufacturing organizations.
• Troubleshoot process development issues using critical and creative thinking.
• Work independently and collaboratively to complete projects.
• Mentor and supervise staff and work effectively with management teams.

Benefits

• Generous benefit options, eligible from the first day of employment.
• Paid training.
• Vacation and holidays, with vacation accrual beginning on the first day of employment.
• Career advancement opportunities.
• Education reimbursement.
• 401k program.
• Learning platform.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior