Senior Research Scientist, Chemical Biology & Proteomics
About The Position
We are seeking a highly motivated and talente d scientist to join our Chemical Biology & Pro teomics (CBP) team at AstraZeneca in Waltham , MA . As a Senior Research Scientist , y ou will be an integral member of a team generating pre-clinical pharmacology data to understand efficacy and selectivity of therapeutic agents . You will have the opportunity to work with a team of cross-functional scientists and support the development of new and successful therapies for patients . If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us.
Requirements
- PhD with 2 + years of post - doc toral / industr ial experience
- Knowledge and hands-on experience with sample preparation and method development on quantitative mass spectrometry (relative and /or absolute protein quantification)
- Experience with mass spectrometry-based covalent screen ing , and p roven expertise with IP-MS or chemical probe- based enrichment MS workflows , and experience developing automated processes to analyze large number of samples for M S analysis
- Skilled in investigating compound effect s under biochemical and cellular settings with q uantitative mass spectrometry , e.g. PTM s, protein complexes perturbations, etc
- Experience in determining protein abundance and turnover by using quantitative proteomics technologies , such as TMT, SILAC, and/ or l abel-free approaches and data independent acquisition (DIA)
- E xpertise in data analysis and an ability to communicate data interpretation clearly
- Significant external reputation gained through professional recognition, external presentation s and publication s in high-impact journals
- Ability to contribute with a positive, result oriented and problem-solving attitude
Nice To Haves
- Experience in pre-clinical drug discovery
- Experience using Thermo Q - E xactive , Orbitrap Exploris , Eclipse, Astra l Zoom or T imsTOF
- Experience with Xcalibur , Proteome Discovere r , MaxQuant , Skyline, Spectronaut and DB search engine tools
- Experience with liquid handling systems and robotic automation
- Famil iarity with targeted proteomics is a plus
Responsibilities
- Develop and employ chemical tools and proteomics technologies to p rovide impactful mechanistic insight s for drug discovery projects across therapeutic areas
- Develop mass spectrometry-based methods to conduct covalent screens
- Design and execute experimental plans to understand target engagement and selectivity profile s of therapeutic agents , understand drug-induced proteome dynamics and investigate post-translational modifications (PTM)
- Represent CBP team , and communicate with project discipline leads, and contribute to generation of mechanistic hypothes i s through i nterpretation of sophisticated proteomics dat a
- M aint ain and troubleshoot LC-MS system
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
