Senior Research Associate, Genome Sciences & Engineering

Stylus Medicine • Cambridge, MA

1d

About The Position

Stylus Medicine is seeking a Senior Research Associate to join its Genome Sciences & Engineering team. The company develops in vivo genetic medicines using engineered recombinases and non-viral delivery. In this role, the associate will drive cell-based assays and high-throughput screening workflows to advance LSR-based genome-editing platforms. The position suits a collaborative, organized, and creative scientist who thrives in a fast-paced environment and tackles complex genome-editing problems.

Requirements

• Bachelor of Science with at least 3 years of relevant experience, or Master of Science with at least 1 year of relevant experience, in cell biology, molecular biology, or a related field.
• Experience conducting high-throughput cell-based screens.
• Hands-on experience with gene-editing technologies such as CRISPR nucleases, recombinases, base editors, or transcriptional effectors.
• Familiarity with laboratory automation platforms for cell-based screening workflows and flow cytometry.
• Experience with nucleic acid quality-control methods, including TapeStation, Qubit, NanoDrop, and qPCR.
• Track record of independently generating precise, reproducible data and performing rigorous quantitative analysis.
• Clear and approachable communication skills, including the ability to present technical information clearly and concisely to diverse audiences.
• Exceptional organizational skills and comfort managing complex datasets and overlapping projects.
• Strategic thinking and ability to plan and prioritize to maximize scientific impact.
• Collaborative, team-first mindset.
• Creative problem-solving skills and ability to thrive amid scientific uncertainty.

Nice To Haves

• Proficiency working with primary T cells, hepatocytes, and/or cancer cell lines.
• Experience working with LNPs.

Responsibilities

• Execute cell-based assays and high-throughput screening workflows to advance platform and program objectives, independently and as part of a cross-functional team.
• Develop and execute arrayed and pooled high-throughput screening campaigns with rigor and reproducibility.
• Troubleshoot experiments, analyze data, and translate results into actionable scientific insights.
• Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team.
• Partner cross-functionally to advance optimized candidates into translational and preclinical development.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior