Senior Research Associate, Histology & Microscopy

Dyne Therapeutics • Waltham, MA

10d • Onsite

About The Position

Dyne Therapeutics is seeking a Senior Research Associate, Histology & Microscopy to independently execute and advance histology and microscopy activities supporting preclinical research programs. The role plans and performs tissue-based studies, optimizes and troubleshoots methods, evaluates data quality, and communicates findings to project teams. The successful candidate will collaborate with scientists across functions, contribute to defined research objectives, and serve as a technical resource for histology workflows, instrumentation, and best practices. The position is based in Waltham, Massachusetts, and cannot be performed fully remotely.

The role includes preparing paraffin- and OCT-embedded rodent and nonhuman primate samples, developing and executing histology and microscopy methods, assessing stained specimens, maintaining equipment and laboratory records, and supporting laboratory safety, quality control, and continuous improvement. The Senior Research Associate will also share technical expertise, train colleagues, and contribute to protocols, standard operating procedures, and best practices.

The stated base pay range is $120,000–$145,000 USD. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. Dyne Therapeutics is an equal opportunity employer.

Requirements

• Bachelor’s degree in histology, biology, or a related scientific field with at least 4 years of relevant experience, or a master’s degree with at least 2 years of relevant experience; equivalent combinations of education and experience will be considered.
• Demonstrated expertise in tissue grossing, processing, paraffin and frozen embedding, microtomy, cryosectioning, staining, microscopy, and histologic quality assessment.
• Hands-on experience handling and grossing rodent and NHP tissues.
• Ability to independently plan and prioritize work, apply scientific and technical judgment, troubleshoot methods, and make recommendations within defined research objectives.
• Strong analytical skills, including evaluating data quality, synthesizing observations, maintaining rigorous documentation, and clearly communicating results to scientific stakeholders.
• Effective collaboration and communication skills, including the ability to work independently, contribute to team goals, and provide technical guidance or training to colleagues.

Nice To Haves

• Experience with plastic embedding.
• Proficiency with laboratory information systems, including PRIMA.
• Certification as a Histotechnologist (HTL) or Histotechnician (HT).

Responsibilities

• Independently plan and perform tissue grossing, processing, embedding, sectioning, and staining for paraffin- and OCT-embedded rodent and NHP samples to support preclinical research objectives.
• Develop, optimize, and execute routine and specialized histology and microscopy methods, adapting approaches to study needs, tissue type, and scientific objectives.
• Troubleshoot technical issues, investigate unexpected results, and recommend improvements to specimen quality, reproducibility, throughput, and laboratory workflows.
• Perform microscopic evaluation and quality assessment of stained specimens; compile results, identify relevant observations, and communicate findings and limitations to scientists and project team leaders.
• Maintain histology and microscopy equipment, including processors, microtomes, embedding centers, and automated stainers; coordinate preventive maintenance, calibration, and vendor support as needed.
• Maintain complete, accurate, and timely laboratory records, protocols, sample tracking, and results in accordance with departmental practices and data integrity standards.
• Apply laboratory safety and quality control standards, identify risks or deviations, and support corrective actions and continuous improvement activities.
• Collaborate with scientists and cross-functional partners to coordinate study activities, manage priorities, and deliver results within established timelines.
• Share technical expertise, train colleagues on histology methods and instrumentation, and contribute to protocols, standard operating procedures, and best practices.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior