Senior Research Associate - High Throughput Cellular Pharmacology

Monte Rosa Therapeutics • Boston, MA

3d

About The Position

Monte Rosa Therapeutics is seeking a motivated High Throughput Cellular Assay expert to contribute to our mission of eliminating disease-causing proteins through targeted protein degradation, an innovative approach that enables us to target proteins once considered undruggable. The ideal candidate will have strong expertise in developing high-throughput cellular assays for screening and compound profiling. You will join a fast-paced and innovative team environment that values teamwork, collaboration, and scientific rigor.

Requirements

• MS or Ph.D. in Molecular Biology, Biochemistry, Biology, or related field.
• The Senior Research Associate II level will have 4-6 years of relevant industrial experience and a Scientist will possess 1-2 years industrial experience
• A thorough understanding of assay principles is required
• Hands-on experience developing and executing cellular assays for lead discovery and optimization is required.
• Relevant assay formats include NanoBRET, cellular HTRF, AlphaLISA, HiBiT, and NanoBiT, Degradation Kinetics.
• Strong collaborative mindset with the ability to thrive in a team-oriented setting.
• Ability to adapt effectively to rapidly approaching deadlines in a dynamic research environment.
• Excellent oral and written communication skills.

Nice To Haves

• Experience working in a drug discovery environment is preferred.
• Experience with compound screening formats, laboratory instrumentation and automation, data analysis and management is preferred.

Responsibilities

• Culture a variety of cell lines and primary cells to develop and optimize high-throughput cellular assays to evaluate target engagement, degradation and pathway modulation
• Utilize automation system to execute cell-based screening and profiling campaigns
• Collaborate within a matrixed environment that integrates multiple functions to drive program decisions.
• Keep meticulous records of experiments on ELN.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior