Pharmacology Principal Research Associate

Vertex Pharmaceuticals•Boston, MA

2d•Onsite

About The Position

The Pharmacology Principal Research Associate is responsible for delivering high-quality, independent research to evaluate the effects of compounds on ex vivo and/or in vivo disease biology. This individual demonstrates advanced technical proficiency, strong attention to detail, and the ability to troubleshoot and adapt methodological approaches. A key focus of this role is the design, execution, and analysis of flow cytometry and cell sorting experiments, particularly using ex vivo samples collected from rodent and large animal studies. The ideal candidate will also have hands-on experience with basic in vivo techniques, including animal handling, dosing via multiple routes of administration (ROAs), perfusion, biofluid collection, tissue dissection/processing, and basic bioanalytical assays such as ELISA using serum and urine samples. While collaborating with their supervisor to set objectives, this individual maintains ownership of experimental design and execution.

Requirements

Strong technical expertise in flow cytometry analysis and cell sorting, including work with ex vivo samples from rodent and large animal tissues
Demonstrated proficiency in designing and interpreting experiments to assess compound effects in ex vivo and/or in vivo disease models
Hands-on experience with basic in vivo pharmacology techniques, including animal handling, dosing via multiple ROAs, perfusion, fluid collection, and tissue dissection/processing
Experience with basic analytical methods, including ELISA assays for serum and urine samples
Solid understanding of core biological and immunological principles
Ability to independently design, execute, and interpret follow-up experiments
Strong analytical skills, including interpretation of complex datasets and refinement of experimental protocols
Proven reliability, particularly in high-impact or sensitive studies
Effective written and verbal communication skills within area(s) of expertise
Bachelor’s degree in a biological science required
Bachelor’s degree with 5+ years of experience, or Master’s degree with 2+ years of experience

Nice To Haves

Developing knowledge of related scientific disciplines; background in muscular dystrophy and/or cystic kidney disease is a plus

Responsibilities

Design, execute, and interpret in vivo experiments with a high degree of independence and reliability
Lead and support flow cytometry analysis and cell sorting workflows for ex vivo samples collected from rodent and large animal studies
Perform sample/cell preparation, staining, acquisition, panel optimization, gating analysis, and sorting with strong technical rigor
Apply sound judgment to prioritize studies based on project impact
Conduct basic in vivo procedures, including: Animal handling, Dosing through multiple routes of administration (ROAs), Perfusion, Blood and other fluid sample collection, Tissue dissection and processing
Perform basic analytical assays, including ELISA analysis of serum and urine samples
Perform basic statistical analyses of experimental data, as appropriate
Independently troubleshoot experimental challenges and refine protocols as needed
Contribute to publication and patent submission processes
Prepare clear, well-structured protocols, study plans, and reports
Stay current with relevant scientific literature and emerging trends
Present findings effectively at internal group, department, or project meetings
Perform additional duties as assigned