Senior Principal Scientist, Cancer Immunology, Discovery Biology, Oncology Thematic Research Center

Bristol Myers Squibb • Seattle, WA

7d • $174,020 - $210,872 • Onsite

About The Position

Bristol Myers Squibb is seeking an innovative immunologist and leader for its Discovery Biology group within the Oncology Thematic Research Center in Seattle, Washington. The role will help shape strategy and advance the company’s portfolio of T cell engager and cancer immunology therapies. The successful candidate will work in a multidisciplinary team, drive discovery projects from concept to clinic using proprietary technologies, collaborate with experts and external partners, and help bring internal and external assets to patients. The position also includes defining strategy, mentoring junior scientists, and leading matrixed teams. The Oncology Thematic Research Center conducts integrated drug discovery, translational research, and early clinical development, using in vitro, in vivo, and ex vivo models to identify and validate targets and therapeutic approaches.

Requirements

• Bachelor’s degree and 10 or more years of academic and/or industry experience; or a master’s degree and 8 or more years; or a Ph.D. or equivalent advanced degree in the life sciences and 6 or more years.
• At least 2 years of leadership experience.
• Strong leadership, interpersonal, and communication skills.
• Ability to manage and prioritize multiple projects and coordinate in-house research with collaborative work.
• Ability to summarize and interpret complex scientific data clearly, concisely, and accurately.
• Strong problem-solving skills and understanding of complex scientific principles.
• Demonstrated experience leveraging AI to refine strategic and tactical planning.

Nice To Haves

• Ph.D. or equivalent advanced degree in the life sciences.
• At least 6 years of industry experience.
• Experience developing novel cancer immune therapeutic approaches, including T cell redirected therapies.
• Experience leading teams profiling and developing complex biologics to enhance immune function in the tumor microenvironment, preferably in discovery of T cell engagers.
• Experience with high-throughput screening and biologically complex cell-based assays to generate mechanistic insight and prioritize therapeutic leads.
• Experience interpreting in vivo functional assays.
• Experience leading and collaborating across matrixed discovery programs from concept to IND, including programs involving immune cell engagers.
• Experience contributing to an IND.
• Experience leading, coaching, and mentoring a team of laboratory-based in vitro biologists.
• Excellent oral and written communication skills and ability to communicate effectively with peers, supervisors, and governance committees.

Responsibilities

• Lead matrixed T cell engager and cancer immunology discovery teams from target concept to IND.
• Lead and mentor a biology team supporting in vitro experimentation.
• Deploy existing and new techniques for function-based identification and selection of lead drug candidates.
• Use scientific experience and insights to shape overall strategy and inform future therapeutic innovation.
• Collaborate with functional area leads, including pharmacology, DMPK, and bioinformatics, to advance programs and define priorities and risks.
• Collaborate with multidisciplinary external partner teams to advance assets.
• Present complex concepts to audiences including governance committees and full project teams.
• Communicate through email, meetings, and reports.

Benefits

• Wellbeing support.
• Retirement and financial protection benefits.
• Medical, dental, vision, life, and disability insurance offerings.
• Flexible Time Off for eligible U.S.-based exempt employees, subject to manager approval.
• 11 paid company holidays each year.
• Eligible employees may receive paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees may receive an annual Global Shutdown between Christmas Day and New Year's Day.
• Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires, 11 paid company holidays, and 3 optional holidays, subject to applicable terms and approval.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior