Senior Principal Scientist – DMPK Project Representative

Bristol Myers Squibb • Needham, MA

1d • $194,710 - $235,942 • Onsite

About The Position

We seek an innovative, self-motivated, exceptional scientist to join our Drug Metabolism and Pharmacokinetic (DMPK) department at our Cambridge, MA site. The role is a senior scientific leader responsible for shaping DMPK strategy across oligonucleotide discovery programs from target validation through candidate selection. This role provides strategic leadership in ADME, pharmacokinetics, PK/PD, and translational science, influences compound design and progression, and represents DMPK on multidisciplinary teams to support high-quality decision-making across the portfolio.

Requirements

• Ph.D. in pharmacokinetics, drug metabolism, pharmacology, or related discipline with 6+ years of industrial experience
• Deep expertise in ADME, PK/PD modelling with experience in Oligonucleotide / ASO pharmacokinetics and disposition
• Demonstrated ability to lead and influence drug discovery programs and candidate selection
• Excellent interpersonal, organizational, oral/written communication skills
• A strong team player with ability to collaborate and build trustworthy relationships with other disciplines for idea generation, issue resolution and program advancement

Responsibilities

• Lead DMPK strategy for oligonucleotide discovery programs from early discovery through candidate nomination, identifying risks and enabling data-driven decisions.
• Provide modality-specific expertise in oligonucleotide disposition, including tissue distribution, uptake, metabolism, stability, and exposure-response relationships.
• Design and interpret in vitro and in vivo DMPK studies and integrate findings from bioanalysis, pharmacology, and toxicology to guide compound optimization.
• Apply translational and model-informed approaches to predict human PK/PD, dose, and regimen strategies for ASO therapeutics.
• Represent DMPK on cross-functional teams, influence portfolio decisions, and mentor scientists while advancing innovative platform capabilities.

Benefits

• Medical, pharmacy, dental, and vision care.
• Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees))
• 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree