Senior Director, DMPK

Crinetics Pharmaceuticals•San Diego, CA

1d•$230,000 - $288,000•Onsite

About The Position

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. The Senior Director, DMPK, reporting to the Vice President, DMPK, will apply their strong scientific training in DMPK and hands-on experience addressing ADME liabilities across drug discovery and development programs. The ideal candidate will have a demonstrated history of leading high-performing DMPK teams within the biotechnology or pharmaceutical industry and contributing to the development of strategic plans, objectives, and practices for the broader DMPK function. In this role, the individual will work closely with chemists, biologists, and toxicologists to develop strategies that advance discovery programs into the clinic. The role also includes close collaboration with Clinical Pharmacology and CMC teams, providing scientific leadership to address drug metabolism and clinical drug-drug interaction issues arising during both early and late-stage development. Overall, this individual will partner across functions to support all stages of preclinical pharmacokinetic assessment, from compound screening through IND- and NDA-enabling activities and regulatory submissions. This role is based out of the headquarters in San Diego.

Requirements

PhD in relevant discipline with 13+ years of relevant experience in pharmaceutical or life sciences industry.
Applicants with BS or MS degrees may apply, but must demonstrate a minimum of 15+ years of significant and relevant experience.
Minimum supervisory experience of 10+ years.
Excellent verbal, written, and interpersonal communication skills are required.
Prior experience working at a small to mid-sized company with wide ranging related responsibilities is desired.
Excellent problem-solving ability.
Demonstration of cross-functional understanding related to drug discovery and development.
Good judge of risks and a keen ability to analyze options and manage outcomes.
Leadership and management skills and demonstrated qualities in this area.
Excellent negotiation skills and a tactful approach that leads to high value on outcomes achieved.

Responsibilities

Provide strategic leadership and oversight for the Drug Metabolism and Pharmacokinetics function within Discovery.
Lead the development and execution of DMPK strategies for candidate evaluation, including the continued expansion and optimization of training, methodologies, and equipment.
Serve as the DMPK representative on multifunctional discovery and early development program teams.
Partner with Discovery colleagues to define optimal lead candidate characteristics, establish appropriate testing strategies, and design, conduct, and report preclinical studies that efficiently characterize potential drug candidates.
Foster effective cross-functional collaboration, particularly with in vitro and in vivo Pharmacology and Toxicology, and provide guidance on lead optimization, PK/PD understanding, and human dose projections.
Oversee and contribute to the preparation of preclinical pharmacokinetic sections of regulatory documents, including INDs, NDAs, briefing books, and Investigator Brochures.
Foster a team culture that promotes continuous improvement, accountability, professional growth, and inclusion.
Recommend, initiate, and lead innovative technologies and approaches that enhance scientific impact and operational efficiency while ensuring the application of cutting-edge science to project-related challenges.
Build strong partnerships across Crinetics, serve as a subject matter expert, and educate cross-functional teams on the application of DMPK principles to drug development.
Identify the need for clinical drug interaction studies based on a strong understanding of metabolic and transporter-mediated drug interactions.
Serve as a subject matter expert and support responses to regulatory queries related to DMPK.
Partner with Discovery leadership to recruit scientists and build teams that supports the DMPK strategy and advances the discovery and development portfolio.
Perform other duties as assigned.